Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/103767
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Aires, Inês Dinis | - |
dc.contributor.author | Ribeiro-Rodrigues, Teresa | - |
dc.contributor.author | Boia, Raquel Sofia Freitas | - |
dc.contributor.author | Ferreira-Rodrigues, Magda | - |
dc.contributor.author | Girão, Henrique | - |
dc.contributor.author | Ambrósio, António Francisco | - |
dc.contributor.author | Santiago, Ana Raquel | - |
dc.date.accessioned | 2022-11-25T11:43:40Z | - |
dc.date.available | 2022-11-25T11:43:40Z | - |
dc.date.issued | 2021-05-21 | - |
dc.identifier.issn | 2218-273X | - |
dc.identifier.uri | https://hdl.handle.net/10316/103767 | - |
dc.description.abstract | Microglial cells are the neuroimmune competent cells of the central nervous system. In the adult, microglia are responsible for screening the neuronal parenchyma searching for alterations in homeostasis. Chronic neuroinflammation plays a role in neurodegenerative disease. Indeed, microglia-mediated neuroinflammation is involved in the onset and progression of several disorders in the brain and retina. Microglial cell reactivity occurs in an orchestrated manner and propagates across the neural parenchyma spreading the neuroinflammatory signal from cell to cell. Extracellular vesicles are important vehicles of intercellular communication and act as message carriers across boundaries. Extracellular vesicles can be subdivided in several categories according to their cellular origin (apoptotic bodies, microvesicles and exosomes), each presenting, different but sometimes overlapping functions in cell communication. Mounting evidence suggests a role for extracellular vesicles in regulating microglial cell action. Herein, we explore the role of microglial extracellular vesicles as vehicles for cell communication and the mechanisms that trigger their release. In this review we covered the role of microglial extracellular vesicles, focusing on apoptotic bodies, microvesicles and exosomes, in the context of neurodegeneration and the impact of these vesicles derived from other cells in microglial cell reactivity. | pt |
dc.description.sponsorship | This research was funded by Foundation for Science and Technology (FCT), Portugal (Strategic Projects UID/NEU/04539/2019, UIDB/04539/2020 and UIDP/01/2020); PhD fellowships PD/BD/52294/2013, PD/BD/114115/2015 and PD/BD/127821/2016), COMPETE-FEDER (FCOMP-01-0124-FEDER-028417; and POCI-01-0145-FEDER-007440), Centro 2020 Regional Operational Programme (CENTRO-01-0145-FEDER-000008: BRAINHEALTH 2020; CENTRO-01-0145- FEDER-000012-N2323: HealthyAging2020), Banco Santander Totta (grant FMUC-BST-2016-224). | - |
dc.language.iso | eng | pt |
dc.publisher | MDPI AG | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | exosomes | pt |
dc.subject | extracellular vesicles | pt |
dc.subject | microglia | pt |
dc.subject | microvesicles | pt |
dc.subject | neurodegeneration | pt |
dc.title | Microglial Extracellular Vesicles as Vehicles for Neurodegeneration Spreading | pt |
dc.type | article | pt |
degois.publication.firstPage | 770 | pt |
degois.publication.issue | 6 | pt |
degois.publication.title | Biomolecules | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/biom11060770 | - |
degois.publication.volume | 11 | pt |
dc.date.embargo | 2021-05-21 | * |
dc.identifier.pmid | 34063832 | - |
uc.date.periodoEmbargo | 0 | pt |
dc.identifier.eissn | 2218-273X | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-0477-1641 | - |
Appears in Collections: | I&D ICBR - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Microglial-extracellular-vesicles-as-vehicles-for-neurodegeneration-spreadingBiomolecules.pdf | 1.15 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License