Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/103762
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Coimbra, Susana | - |
dc.contributor.author | Reis, Flávio | - |
dc.contributor.author | Valente, Maria João | - |
dc.contributor.author | Rocha, Susana | - |
dc.contributor.author | Catarino, Cristina | - |
dc.contributor.author | Rocha-Pereira, Petronila | - |
dc.contributor.author | Sameiro-Faria, Maria | - |
dc.contributor.author | Bronze-da-Rocha, Elsa | - |
dc.contributor.author | Belo, Luís | - |
dc.contributor.author | Santos-Silva, Alice | - |
dc.date.accessioned | 2022-11-25T10:27:29Z | - |
dc.date.available | 2022-11-25T10:27:29Z | - |
dc.date.issued | 2021-05-16 | - |
dc.identifier.issn | 2227-9059 | - |
dc.identifier.uri | https://hdl.handle.net/10316/103762 | - |
dc.description.abstract | Dyslipidemia is a major traditional risk factor for cardiovascular disease (CVD) in chronic kidney disease (CKD) patients, although the altered lipid profile does not explain the number and severity of CVD events. High-density lipoprotein (HDL) is a heterogeneous (size, composition, and functionality) population of particles with different atherogenic or atheroprotective properties. HDL-cholesterol concentrations per se may not entirely reflect a beneficial or a risk profile for CVD. Large HDL in CKD patients may have a unique proteome and lipid composition, impairing their cholesterol efflux capacity. This lack of HDL functionality may contribute to the paradoxical coexistence of increased large HDL and enhanced risk for CVD events. Moreover, CKD is associated with inflammation, oxidative stress, diabetes, and/or hypertension that are able to interfere with the anti-inflammatory, antioxidative, and antithrombotic properties of HDL subpopulations. How these changes interfere with HDL functions in CKD is still poorly understood. Further studies are warranted to fully clarify if different HDL subpopulations present different functionalities and/or atheroprotective effects. To achieve this goal, the standardization of techniques would be valuable. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI AG | pt |
dc.relation | UIDP/04539/2020 (CIBB) | pt |
dc.relation | PTDC/SAU-NUT/31712/2017 | pt |
dc.relation | PO-CI-01-0145-FEDER- 007440 | pt |
dc.relation | CENTRO-01-0145-FEDER-000012-HealthyAging2020 | pt |
dc.relation | UIDP/04378/2020 | pt |
dc.relation | UIDB/04378/2020 | pt |
dc.relation | Norte-01-0145-FEDER-000024 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | HDL subpopulations | pt |
dc.subject | cardiovascular disease risk | pt |
dc.subject | chronic kidney disease | pt |
dc.subject | inflammation | pt |
dc.subject | oxidative stress | pt |
dc.subject | HDL functionality | pt |
dc.title | Subpopulations of High-Density Lipoprotein: Friends or Foes in Cardiovascular Disease Risk in Chronic Kidney Disease? | pt |
dc.type | article | pt |
degois.publication.firstPage | 554 | pt |
degois.publication.issue | 5 | pt |
degois.publication.title | Biomedicines | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/biomedicines9050554 | - |
degois.publication.volume | 9 | pt |
dc.date.embargo | 2021-05-16 | * |
dc.identifier.pmid | 34065648 | - |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology | - |
crisitem.project.grantno | Applied Molecular Biosciences Unit | - |
crisitem.project.grantno | Applied Molecular Biosciences Unit - UCIBIO | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CEAACP - Center for Studies in Archeology, Arts and Heritage | - |
crisitem.author.orcid | 0000-0003-3401-9554 | - |
crisitem.author.orcid | 0000-0002-6137-5995 | - |
Appears in Collections: | I&D ICBR - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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Subpopulations-of-highdensity-lipoprotein-Friends-or-foes-in-cardiovascular-disease-risk-in-chronic-kidney-diseaseBiomedicines.pdf | 723.73 kB | Adobe PDF | View/Open |
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