Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/103690
DC Field | Value | Language |
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dc.contributor.author | Dewaeles, Edmone | - |
dc.contributor.author | Carvalho, Kévin | - |
dc.contributor.author | Fellah, Sandy | - |
dc.contributor.author | Sim, Jaewon | - |
dc.contributor.author | Boukrout, Nihad | - |
dc.contributor.author | Caillierez, Raphaelle | - |
dc.contributor.author | Ramakrishnan, Hariharan | - |
dc.contributor.author | Van der Hauwaert, Cynthia | - |
dc.contributor.author | Vijaya Shankara, Jhenkruthi | - |
dc.contributor.author | Martin, Nathalie | - |
dc.contributor.author | Massri, Noura | - |
dc.contributor.author | Launay, Agathe | - |
dc.contributor.author | Folger, Joseph K | - |
dc.contributor.author | Schutter, Clémentine de | - |
dc.contributor.author | Larrue, Romain | - |
dc.contributor.author | Loison, Ingrid | - |
dc.contributor.author | Goujon, Marine | - |
dc.contributor.author | Jung, Matthieu | - |
dc.contributor.author | Le Gras, Stéphanie | - |
dc.contributor.author | Gomez-Murcia, Victoria | - |
dc.contributor.author | Faivre, Emilie | - |
dc.contributor.author | Lemaire, Julie | - |
dc.contributor.author | Garat, Anne | - |
dc.contributor.author | Beauval, Nicolas | - |
dc.contributor.author | Maboudou, Patrice | - |
dc.contributor.author | Gnemmi, Viviane | - |
dc.contributor.author | Gibier, Jean-Baptiste | - |
dc.contributor.author | Buée, Luc | - |
dc.contributor.author | Abbadie, Corinne | - |
dc.contributor.author | Glowacki, Francois | - |
dc.contributor.author | Pottier, Nicolas | - |
dc.contributor.author | Perrais, Michael | - |
dc.contributor.author | Cunha, Rodrigo A. | - |
dc.contributor.author | Annicotte, Jean-Sébastien | - |
dc.contributor.author | Laumet, Geoffroy | - |
dc.contributor.author | Blum, David | - |
dc.contributor.author | Cauffiez, Christelle | - |
dc.date.accessioned | 2022-11-21T14:37:49Z | - |
dc.date.available | 2022-11-21T14:37:49Z | - |
dc.date.issued | 2022-11-15 | - |
dc.identifier.issn | 1558-8238 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/103690 | - |
dc.description.abstract | Cisplatin is a potent chemotherapeutic drug that is widely used in the treatment of various solid cancers. However, its clinical effectiveness is strongly limited by frequent severe adverse effects, in particular nephrotoxicity and chemotherapy-induced peripheral neuropathy. Thus, there is an urgent medical need to identify novel strategies that limit cisplatin-induced toxicity. In the present study, we show that the FDA-approved adenosine A2A receptor antagonist istradefylline (KW6002) protected from cisplatin-induced nephrotoxicity and neuropathic pain in mice with or without tumors. Moreover, we also demonstrate that the antitumoral properties of cisplatin were not altered by istradefylline in tumor-bearing mice and could even be potentiated. Altogether, our results support the use of istradefylline as a valuable preventive approach for the clinical management of patients undergoing cisplatin treatment. | pt |
dc.language.iso | eng | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | G protein–coupled receptors | pt |
dc.subject | Nephrology | pt |
dc.subject | Pharmacology | pt |
dc.subject.mesh | Animals | pt |
dc.subject.mesh | Mice | pt |
dc.subject.mesh | Cisplatin | pt |
dc.subject.mesh | Purines | pt |
dc.subject.mesh | Receptor, Adenosine A2A | pt |
dc.subject.mesh | Neuralgia | pt |
dc.subject.mesh | Antineoplastic Agents | pt |
dc.title | Istradefylline protects from cisplatin-induced nephrotoxicity and peripheral neuropathy while preserving cisplatin antitumor effects | pt |
dc.type | article | - |
degois.publication.issue | 22 | pt |
degois.publication.title | The Journal of Clinical Investigation | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1172/JCI152924 | pt |
degois.publication.volume | 132 | pt |
dc.date.embargo | 2022-11-15 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0003-2550-6422 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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Istradefylline protects from cisplatin-induced nephrotoxicity.pdf | 10.84 MB | Adobe PDF | View/Open |
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This item is licensed under a Creative Commons License