Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/103249
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Carvalho da Silva, António M | - |
dc.contributor.author | Lemos, Cristina | - |
dc.contributor.author | Silva, Henrique Bernardo | - |
dc.contributor.author | Ferreira, Ildete L. | - |
dc.contributor.author | Tomé, Ângelo R. | - |
dc.contributor.author | Rego, A. Cristina | - |
dc.contributor.author | Cunha, Rodrigo A. | - |
dc.date.accessioned | 2022-10-26T10:36:44Z | - |
dc.date.available | 2022-10-26T10:36:44Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 1663-4365 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/103249 | - |
dc.description.abstract | Alzheimer's disease (AD) is characterized by progressive memory deficits accompanied by synaptic and metabolic deficits, namely of mitochondrial function. AD patients also display a disrupted circadian pattern. Thus, we now compared memory performance, synaptic plasticity, and mitochondria function in 24-week-old non-transgenic (non-Tg) and triple transgenic male mice modeling AD (3xTg-AD) at Zeitgeber 04 (ZT-4, inactive phase) and ZT-16 (active phase). Using the Morris water maze test to minimize the influence of circadian-associated locomotor activity, we observed a circadian variation in hippocampus-dependent learning performance in non-Tg mice, which was impaired in 3xTg-AD mice. 3xTg-AD mice also displayed a lack of circadian variation of their performance in the reversal spatial learning task. Additionally, the amplitude of hippocampal long-term potentiation also exhibited a circadian profile in non-Tg mice, which was not observed in 3xTg-AD mice. Moreover, cerebral cortical synaptosomes of non-Tg mice also displayed a circadian variation of FCCP-stimulated oxygen consumption as well as in mitochondrial calcium retention that were blunted in 3xTg-AD mice. In sum, this multidimensional study shows that the ability to maintain a circadian oscillation in brain behavior, synaptic plasticity, and synaptic mitochondria function are simultaneously impaired in 3xTg-AD mice, highlighting the effects of circadian misalignment in AD. | pt |
dc.language.iso | eng | pt |
dc.relation | La Caixa Foundation (LCF/PR/HP17/52190001) | pt |
dc.relation | Centro 2020 (CENTRO-01- 0145-FEDER-000008:BrainHealth 2020, CENTRO-01-0145- FEDER-000012-HealthyAging2020, and CENTRO-01-0246- FEDER-000010) | pt |
dc.relation | FCT - POCI-01-0145-FEDER-03127, POCI-01-0145-FEDER-032316, UIDP/04539/2020, and UIDB/04539/2020) | pt |
dc.relation | FCT - SFRH/BD/51667/2011 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | circadian | pt |
dc.subject | Alzheimer’s disease | pt |
dc.subject | behavior | pt |
dc.subject | LTP | pt |
dc.subject | mitochondria | pt |
dc.subject | Zeitgeber | pt |
dc.subject | hippocampus | pt |
dc.title | Simultaneous Alteration of the Circadian Variation of Memory, Hippocampal Synaptic Plasticity, and Metabolism in a Triple Transgenic Mouse Model of Alzheimer's Disease | pt |
dc.type | article | - |
degois.publication.firstPage | 835885 | pt |
degois.publication.title | Frontiers in Aging Neuroscience | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3389/fnagi.2022.835885 | pt |
degois.publication.volume | 14 | pt |
dc.date.embargo | 2022-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0003-3182-6289 | - |
crisitem.author.orcid | 0000-0002-7234-3411 | - |
crisitem.author.orcid | 0000-0001-6552-4479 | - |
crisitem.author.orcid | 0000-0003-0700-3776 | - |
crisitem.author.orcid | 0000-0003-2550-6422 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais IIIUC - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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fnagi-14-835885.pdf | 2.28 MB | Adobe PDF | View/Open |
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