Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/102616
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Ivanova, Vilena V | - |
dc.contributor.author | Khaiboullina, Svetlana F | - |
dc.contributor.author | Cherenkova, Ekaterina E | - |
dc.contributor.author | Martynova, Ekaterina V | - |
dc.contributor.author | Nevzorova, Tatiana A | - |
dc.contributor.author | Kunst, Michail A | - |
dc.contributor.author | Sibgatullin, Timur B | - |
dc.contributor.author | Maksudova, Adelia N | - |
dc.contributor.author | Oliveira, Paulo J. | - |
dc.contributor.author | Lombardi, Vincent C | - |
dc.contributor.author | Palotas, Andras | - |
dc.contributor.author | Rizvanov, Albert A | - |
dc.date.accessioned | 2022-10-04T10:01:46Z | - |
dc.date.available | 2022-10-04T10:01:46Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1421-9778 | pt |
dc.identifier.issn | 1015-8987 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/102616 | - |
dc.description.abstract | Circulating auto-reactive antibodies are hallmark features of auto-immune diseases, however little is known with respect to the specificity of such bio-markers. In the present study, we investigated the specificity of anti-nucleic acid antibodies in the blood of subjects with systemic lupus erythematosus (SLE) and healthy controls. Methods: Sera from 12 SLE cases and 8 controls were evaluated for immuno-reactivity to purified RNA, DNA and mitochondrial DNA (mtDNA) by enzyme-linked immuno-sorbent assay (ELISA). Results: As expected, immuno-reactivity to total nucleic acids was significantly higher in subjects with SLE when compared to healthy controls, however a clear distinction was observed among the various nucleic acid sub-types, with sera from SLE subjects displaying the greatest immunoreactivity to RNA followed by mtDNA and then total DNA. Conclusion: The identification of auto-reactive antibodies can serve as highly sensitive biomarkers, although their specificity may not always allow diagnostic certainty. The knowledge that auto-antibodies in subjects with SLE display differential immuno-reactivity may help to improve existing diagnostics and may lead to a better understanding of the pathogenesis of auto-immune disorders. | pt |
dc.language.iso | eng | pt |
dc.relation | Russian Government Program of Competitive Growth of Kazan Federal University and funded by the subsidy allocated to Kazan Federal University for the state assignment in the sphere of scientific activities. | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | pt |
dc.subject | Auto-antibody | pt |
dc.subject | Auto-antigens | pt |
dc.subject | Auto-immune disease | pt |
dc.subject | Biomarker | pt |
dc.subject | Mitochondri | pt |
dc.subject | Nucleic acid | pt |
dc.subject | Systemic lupus erythematosus (SLE) | pt |
dc.subject.mesh | Adolescent | pt |
dc.subject.mesh | Adult | pt |
dc.subject.mesh | DNA | pt |
dc.subject.mesh | DNA, Mitochondrial | pt |
dc.subject.mesh | Enzyme-Linked Immunosorbent Assay | pt |
dc.subject.mesh | Female | pt |
dc.subject.mesh | Genome, Human | pt |
dc.subject.mesh | HEK293 Cells | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Lupus Erythematosus, Systemic | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Mitochondria | pt |
dc.subject.mesh | RNA | pt |
dc.title | Differential immuno-reactivity to genomic DNA, RNA and mitochondrial DNA is associated with auto-immunity | pt |
dc.type | article | - |
degois.publication.firstPage | 2200 | pt |
degois.publication.lastPage | 2208 | pt |
degois.publication.issue | 6 | pt |
degois.publication.title | Cellular Physiology and Biochemistry | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1159/000369663 | pt |
degois.publication.volume | 34 | pt |
dc.date.embargo | 2014-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-5201-9948 | - |
Aparece nas coleções: | I&D CNC - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Differential-immunoreactivity-to-genomic-DNA-RNA-and-mitochondrial-DNA-is-associated-with-autoimmunityCellular-Physiology-and-Biochemistry.pdf | 1.21 MB | Adobe PDF | Ver/Abrir |
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