Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/102546
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dc.contributor.authorLoureiro, Cláudia Chaves-
dc.date.accessioned2022-09-30T08:10:45Z-
dc.date.available2022-09-30T08:10:45Z-
dc.date.issued2016-
dc.identifier.issn21735115pt
dc.identifier.urihttps://hdl.handle.net/10316/102546-
dc.description.abstractBecause asthma and COPD are both inflammatory chronic obstructive airway diseases, there are several clinical expressions which can cause confusion, such as: eosinophilic asthma with fixed obstruction, which is a risk factor and might progress to COPD; eosinophilic COPD; COPD with partial reversible obstruction with no asthmatic component and also eosinophilic asthma-COPD overlap syndrome (ACOS). While at the two extremes of these disorders the pathoimmunological processes are clearly different, in some patients there is overlap and the pathophysiological border between asthma and COPD is fused (or diffuse). The current guidelines are clearly insufficient for classification of the obstructive patients and, taking into account that binary separation between the two diseases is not completely clear, we should resist the temptation to label patients as ACOS and consider new airway disease taxonomy. Regardless of the condition concerned, eosinophils should be considered in the algorithm approach to obstructive patients: in COPD, as in asthma, they are related to the underlying pathological process; they have prognostic value and are related to therapeutic response. Therefore, eosinophils should be valued as useful biomarkers and included in a multidimensional diagnostic and therapeutic approach, bearing in mind the phenotypic, immunopathological and functional complexity of chronic obstructive airway disease.pt
dc.language.isoengpt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt
dc.subjectACOSpt
dc.subjectAsthmapt
dc.subjectCOPDpt
dc.subjectEosinophiliapt
dc.subject.meshAsthmapt
dc.subject.meshEosinophilspt
dc.subject.meshHumanspt
dc.subject.meshPhenotypept
dc.subject.meshPulmonary Disease, Chronic Obstructivept
dc.subject.meshPulmonary Eosinophiliapt
dc.subject.meshSyndromept
dc.titleBlurred lines. Eosinophilic COPD: ACOS or COPD phenotype?pt
dc.typearticle-
degois.publication.firstPage279pt
degois.publication.lastPage282pt
degois.publication.issue5pt
degois.publication.titleRevista Portuguesa de Pneumologia (English Edition)pt
dc.peerreviewedyespt
dc.identifier.doi10.1016/j.rppnen.2016.01.006pt
degois.publication.volume22pt
dc.date.embargo2016-01-01*
uc.date.periodoEmbargo0pt
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypearticle-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextCom Texto completo-
item.languageiso639-1en-
Appears in Collections:FMUC Medicina - Artigos em Revistas Nacionais
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