Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/10170
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Carvalho, Arsélio Pato de | - |
dc.contributor.advisor | Madeira, Vítor Manuel Calado | - |
dc.contributor.author | Carvalho, Caetana Angélica Ermitão Monteiro de | - |
dc.date.accessioned | 2009-05-25T10:01:32Z | - |
dc.date.available | 2009-05-25T10:01:32Z | - |
dc.date.issued | 1980-02-29 | - |
dc.identifier.citation | CARVALHO, Caetana Angélica Ermitão Monteiro de - Interacção de catiões com membranas do músculo e do cérebro. Coimbra, 1979. | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/10170 | - |
dc.description | Tese de doutoramento em Biologia Físico-Química apresentada à Fac. de Ciências e Tecnologia de Coimbra | en_US |
dc.description.abstract | The Ca2+ stimulated ATPase activity of sarcoplasmic reticulum ( SR ) is activated after a short period of preincubation at temperatures between 40 and 450C, but for temperatures higher than 480C pronounced denaturation is observed. Heat denaturation is decreased if Mg2+ or K+ are present which is attributed to stabilization by cations of the ATPase Ca2+ transport coupled to the ATPase activity in SR was followed by using the chlorotetracycline ( CTC ) fluorescense technique, and it is concluded that the Ca2+ accumulated in the presence of ATP is mostly bound to the membranes. The fluorescence of CTC was also utilized to follow the interaction of Ca2+ with brain membranes, and the technique was found to be useful to monitor the binding and release of Ca2+ in synaptosomes and other brain membrane fractions. The passive permeability of synaptosomes to electrolytes and non-electrolytes is temperature dependent. Furthermore, the fluxes of Ca2+, Sr2+ and Mg2+ were studied and the results suggest that the efflux of Ca2+ in synaptosomes is induced selectively by Na+, which is a major mechanism responsible for the regulation of Ca2+ in the nerve cell. | en_US |
dc.language.iso | por | en_US |
dc.rights | embargoedAccess | eng |
dc.subject | Biologia celular | - |
dc.title | Interacção de catiões com membranas do músculo e do cérebro | en_US |
dc.type | doctoralThesis | en_US |
item.fulltext | Sem Texto completo | - |
item.grantfulltext | none | - |
item.languageiso639-1 | pt | - |
item.cerifentitytype | Publications | - |
item.openairetype | doctoralThesis | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Appears in Collections: | FCTUC Ciências da Vida - Teses de Doutoramento |
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