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Title: Maternal high-fat high-sucrose diet and gestational exercise modulate hepatic fat accumulation and liver mitochondrial respiratory capacity in mothers and male offspring
Authors: Stevanović-Silva, Jelena
Beleza, Jorge
Coxito, Pedro
Pereira, Susana
Rocha, Hugo
Gaspar, Tiago Bordeira
Gärtner, Fátima
Correia, Rossana
Martins, Maria João
Guimarães, Tiago João 
Martins, Sandra Liliana Carvalho 
Oliveira, Paulo J
Ascensão, António 
Magalhães, José
Keywords: Fetal programming; Gestational diabetes; Liver mitochondria; Physical activity; Pregnancy
Issue Date: 2021
Volume: 116
Abstract: Maternal high-caloric nutrition and related gestational diabetes mellitus (GDM) are associated with a high-risk for developing metabolic complications later in life and in their offspring. In contrast, exercise is recognized as a non-pharmacological strategy against metabolic dysfunctions associated to lifestyle disorders. Therefore, we investigated whether gestational exercise delays the development of metabolic alterations in GDM mothers later in life, but also protects 6-week-old male offspring from adverse effects of maternal diet.
ISSN: 00260495
DOI: 10.1016/j.metabol.2021.154704
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais

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