Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/100567
DC FieldValueLanguage
dc.contributor.authorAlmeida, Rui-
dc.contributor.authorAbrantes, Carlos-
dc.contributor.authorGigliano, Davide-
dc.contributor.authorOliveira, Rui Caetano-
dc.contributor.authorTeixeira, Paulo-
dc.contributor.authorViegas, Marta-
dc.contributor.authorRodrigues, Ângelo-
dc.contributor.authorJulião, Maria José-
dc.date.accessioned2022-07-01T10:33:24Z-
dc.date.available2022-07-01T10:33:24Z-
dc.date.issued2022-
dc.identifier.issn2008-2207pt
dc.identifier.urihttps://hdl.handle.net/10316/100567-
dc.description.abstractBackground: High-grade B-cell lymphoma (HGBL) with rearrangements of MYC and BCL2 and/or BCL6, called double and triple-hit lymphomas (DTH-HGBL), are lymphoid malignancies with inferior outcomes when treated with standard chemotherapy. The identification of DTH-HGBL cases is challenging, considering their variable clinical, morphologic, and immunohistochemical features. Materials and Methods: Retrospective revision of medical data of patients diagnosed with DTH-HGBL confirmed by FISH, between January 2010 and January 2020, in three Tertiary Portuguese Hospitals (Coimbra Hospital and University Center, Portuguese Oncology Institute – Coimbra and Portuguese Oncology Institute – Porto). Pathological features, morphology, and immunohistochemical profile were evaluated by at least two experienced pathologists in hematopoietic and lymphoid neoplasms. Results: The cohort included 24 patients: 33.3% triple-hit, 58.3%, MYC/BCL2 double-hit and 8.3% MYC/BCL6 double-hit. There was no gender predominance, with a median age of 62.5±14.3y, 33.3% were diagnosed as nodal disease, and 66.7% as extranodal. Morphologic features of DLBCL were present in 50% of cases, morphological features of both DLBCL and Burkitt lymphoma (DLBCL/BL) in 45.8% and 4.2% of blastoid morphology. Immunohistochemical evaluation, regarding the Hans algorithm, revealed a Germinal center (GC)/GC-like subtype in 83.3% of cases and a non-GC/non-GC-like subtype in 16.7%. MYC was positive in 42.9% and the median proliferative index was 80±12.4%. Conclusion: DTH-HGBL has a very broad range of features. We consider that a cost-effective approach would be to perform cytogenetic analysis in DLBCL and DLBCL/BL cases with GC/GC-like subtype. MYC and BCL2 immunohistochemistry can be useful to identify patients who may benefit from more aggressive therapies, but not as tools for case selection for FISH.pt
dc.language.isoengpt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt
dc.subjectHigh-gradept
dc.subjectB-cellpt
dc.subjectLymphomapt
dc.subjectCytogeneticspt
dc.subjectImmunohistochemistrypt
dc.subjectDouble-hitpt
dc.subjectTriple-hitpt
dc.titleClinical and Pathological Features of Double-Hit and Triple-Hit High-Grade B-Cell Lymphomas: A Retrospective Study from Three Portuguese Tertiary Centerspt
dc.typearticle-
degois.publication.firstPage94pt
degois.publication.lastPage102pt
degois.publication.issue2pt
degois.publication.titleInternational Journal of Hematology-Oncology and Stem Cell Researchpt
dc.peerreviewedyespt
dc.identifier.doi10.18502/ijhoscr.v16i2.9202pt
degois.publication.volume16pt
dc.date.embargo2022-01-01*
uc.date.periodoEmbargo0pt
item.openairetypearticle-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextCom Texto completo-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
Files in This Item:
File Description SizeFormat
1351-Article Text-6131-1-10-20220412.pdf1.13 MBAdobe PDFView/Open
Show simple item record

Google ScholarTM

Check

Altmetric

Altmetric


This item is licensed under a Creative Commons License Creative Commons