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Title: A Review of the Application of Resorcinarenes and SBA-15 in Drug Delivery
Authors: Galindres, Diana M.
Cifuentes, Diego
Tinoco, Luz Elena
Murillo-Acevedo, Yesid
Rodrigo, M. Melia 
Ribeiro, Ana C. F. 
Esteso, Miguel A. 
Keywords: resorcin[4]arenes; SBA-15; macrocycles; pharmacology; drug delivery; mesoporous silica; adsorbents; host-guest complex
Issue Date: 2022
Project: Fundación Universidad de América (Bogotá, Colombia), project: “Articulación de las Ciencias Básicas y la Ingeniería desde la química y el análisis de modelos matemáticos y de aprendizaje autónomo 
University of Alcalá (Spain), Program: “Stays for Foreign Scientists and Technologists—2021" 
Serial title, monograph or event: Processes
Volume: 10
Issue: 4
Abstract: Due to the diseases that people face today, scientists dedicate a part of their research to the synthesis, characterization, and study of functional compounds for controlled drug delivery. On the one hand, resorcinarenes are macrocycles obtained by condensation reactions of resorcinol and aldehyde. They include an upper and a lower rim functioning with different groups that confer solubility to the macrocycle and favor interactions with other compounds, therefore the hydroxyl groups on the upper rim improve the formation of hydrogen bonds. Additionally, resorcinarenes feature a cavity studied for forming host-guest complexes. SBA-15, on the other hand, is a mesoporous silica characterized by ordered pores in its structure and a large surface area. As a result of its properties, it has been used for several purposes, including absorbents, drug delivery, catalysis, and environmental processes. This review shows the recent advances in synthesis methods, characterization, micelle formation, interaction with other compounds, and host-guest procedures, as well as techniques for evaluating toxicity, drug retention, and their preliminary uses in pharmacology for macrocycles, such as resorcin[4]arenes and SBA-15.
ISSN: 2227-9717
DOI: 10.3390/pr10040684
Rights: openAccess
Appears in Collections:I&D CQC - Artigos em Revistas Internacionais

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