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This work was funded by Portuguese national funds via FCT—Fundação para a Ciência e a Tecnologia under the project PTDC/MED-NEU/3644/2020 and UIDB/04539/2020, UIDP/04539/2020 and LA/P/0058/2020. J.D.M. is supported by PD/BD/146409/2019 PhD fellowship. E.C. is supported by a Junior Investigator contract under the project PTDC/MED-NEU/3644/2020.