This research has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreement No 857188 (PHArA-ON Project), and support of national funds through Fundaç˜ao para a Ciˆencia e Tecnologia, I. P (FCT), under the projects UIDB/04292/2020, UIDP/04292/2020, granted to MARE, LA/P/0069/2020, granted to the Associate Laboratory ARNET, UID/ GEO/04035/2019 granted to GeoBioTec and a Principal Investigator CEEC contract granted to MJF. ARC was supported by a research grant from PROAQUA (REVIVE2021_PhD) and SRQS was supported by a research grant under the project PHArA-ON (H2020-SC1-FA-DTS-2018- 2)