This work was supported by FCT (FundacËão para a Ciência e a Tecnologia), the European Union, QREN, POPH, FEDER and COMPETE [FCT-ANR/IMI-MIC/0041/2012; PTDC/ IMI-MIC/5350/2014; PTDC/BEX-BCM/2121/2014] through the iBiMED (UID/BIM/04501/2013) and QOPNA research units [PTDC/QUI-BIQ/104968/ 2008; UID QUI/UI0062/2013, FCOMP-01-0124-FEDER-037296], and RNEM [LISBOA-01-0145- FEDER-402-022125 that concerns the Portuguese Mass Spectrometry Network), REDE/1504/REM/ 2005]. This work was also financed by the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme under project CENTRO-01-0145- FEDER-000008: BrainHealth 2020, and through the COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation and Portuguese national funds via FCT - FundacËão para a Ciência e a Tecnologia, I.P., under projects POCI- 01-0145-FEDER-016390:CANCEL STEM and POCI- 01-0145-FEDER-007440. Ana R. D. ArauÂjo [SFRH/ BD/78835/2011], Catarina Morais [SFRH/BD/ 79077/2011], Elisabete Maciel [SFRH/BPD/ 104165/2014], Helena Oliveira [SFRH/BPD/ 111736/2015], and TaÃnia Melo [BPD/UI51/5388/ 2017] were supported by FCT grants. Clara Pereira was supported by Fundo Social Europeu and Programa Operacional Potencial Humano through FCT investigator grant IF/00889/2015