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This research was funded by Spanish Ministerio de Ciencia e Innovación (MICINN), grant number CTQ2017-84415-R, CIBER-BBN, grant number CB06_01_0019 and Generalitat de Catalunya, grant number 2017/SGR/114. A.F.J. acknowledges Fundação para a Ciência e Tecnologia (FCT), Portugal, for financial support regarding Post-Doctoral grant (SFRH/BPD/104544/2014). CQC is supported by FCT through the project no. 007630 UID/QUI/00313/2013, co-funded by COMPETE2020-UE. CIBER-BBN is an initiative funded by the VI National R + D + I Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund.