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This work was supported by FCT Ph.D. fellowships (PD/BD/127821/2016 and PD/BD/114115/2015) and Strategic project (UID/NEU/04539/2013); COMPETE-FEDER (POCI- 01-0145-FEDER-007440); Centro 2020 Regional Operational Programme: BRAINHEALTH 2020 (CENTRO-01-0145-FEDER- 000008); Global Ophthalmology Awards Program from Bayer 2015 (US2083156314).