This work was supported by Fundação para a Ciência e a Tecnologia, I.P (FCT, Portugal), projects 03/SAICT/2015, PTDC/EMD-TLM/7289/2020 and PTDC/MEDPAT/ 29395/2017, through national funds and co-funded by FEDER under the PT2020 Partnership. The Coimbra Chemistry Centre (CQC) is supported by FCT through project UID/QUI/00313/2019. This work was also supported by a European Commission Twinning on “Excel in Rare Diseases’ Research: Focus on LYSOsomal Disorders and CILiopathies’ grant (H2020-TWINN-2017: GA 81108). L.S.A. was a holder of a FCT PhD fellowship (PD/BD/114254/2016), attributed by the ProRegem Doctoral Programme in 2016. C.S.L. is also a holder of a FCT PhD fellowship (PD/ BD/135045/2017). A.R.A.M. was funded by the FCT Stimulus of Scientific Employment Individual Support Call 2017 (CEECIND/01006/2017).