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This work was supported by grants from the Swedish Research Council (https://www.vr.se/english.html; D0761801 to JF), Swedish Cancer Society (https://www.cancerfonden.se/omcancerfonden/ about-the-swedish-cancer-society; CAN 2016/505 to JF), Strategic Research Programme in Stem Cells and Regenerative Medicine (StratRegen) (https://ki.se/en/research/ stratregen-research; to JF), Knut och Alice Wallenbergs Stiftelse (https://kaw.wallenberg.org; KAW 2018.0063), Torsten So¨derbergs Stiftelse (professorship to JF), Portuguese Foundation for Science and Technology (https://www.fct.pt/fct. phtml.en; SFRH/BD/33465/2008 to PR), Human Frontiers Long-Term Fellowship (http://www.hfsp. org; LT-000231/2011-L to JEM), Swedish Society for Medicine (https://www.ssmf.se/about-ssmf-inenglish/; SLS505921 to PB).