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This work was supported by national funds through Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Educação (MEC) (Programa de Investimentos e Despesas de Desenvolvimento da Administração Central—PIDDAC), through project references IF/00588/2015 and IF/00407/2013/CP1162/CT0023 as well by Fundo Europeu de Desenvolvimento Regional (FEDER) through project NORTE-01-0145-FEDER-000012 (Structured Programme on Bioengineering Therapies for Infectious) funded by NORTE2020 program. This work was also supported by the Fundação para a Ciência e a Tecnologia (FCT), through the strategic project UID/MAR/04292/2019 granted to MARE. Thanks, are also due, for the financial support, to CESAM (UID/AMB/50017) through FCT/MEC national funds.