The research leading to these results has received support from the Innovative Medicines Initiative Joint Undertaking under EMIF grant agreement n° 115372, the resources of which are composed of financial contribution from the European Union’s Seventh Framework Programme (FP7/2007–2013) and EFPIA companies’ in-kind contribution. This work was also financed by the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme under project CENTRO-01- 0145-FEDER-000008:BrainHealth 2020, and through the COMPETE 2020—- Operational Programme for Competitiveness and Internationalisation and Portuguese national funds via FCT—Fundação para a Ciência e a Tecnologia, I.P., under project POCI-01-0145-FEDER-007440. MJL and DD were supported by the Portuguese Foundation for Science and Technology (refs PD/BD/ 135108/2017 and SFRH/BD/52289/2013, respectively)