This work was supported by Foundation for Science and Technology (FCT), FEDER and COMPETE (FCOMP-01-0124-FEDER-041099), EXPL/BIM-MED/0822/2013, SFRH/BD/90365/2012, SFRH/BD/79526/2011, L’Oréal-UNESCO Portugal for Women in Science, EC (ERC project nº 307384, “Nanotrigger”) and co-funded by FEDER (QREN), through Programa Mais Centro under project CENTRO-07-ST24-FEDER-002008 and PEst-C/SAU/UI0709/2011. This work was also supported by FEDER funds through the POCI - COMPETE 2020 - Operational Programme Competitiveness and Internationalisation in Axis I - Strengthening research, technological development and innovation (Project No. 007491) and National Funds by FCT (Project UID/Multi /00709)

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This work was supported by Foundation for Science and Technology (FCT), FEDER and COMPETE (FCOMP-01-0124-FEDER-041099), EXPL/BIM-MED/0822/2013, SFRH/BD/90365/2012, SFRH/BD/79526/2011, L’Oréal-UNESCO Portugal for Women in Science, EC (ERC project nº 307384, “Nanotrigger”) and co-funded by FEDER (QREN), through Programa Mais Centro under project CENTRO-07-ST24-FEDER-002008 and PEst-C/SAU/UI0709/2011. This work was also supported by FEDER funds through the POCI - COMPETE 2020 - Operational Programme Competitiveness and Internationalisation in Axis I - Strengthening research, technological development and innovation (Project No. 007491) and National Funds by FCT (Project UID/Multi /00709)