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Title: Cytoskeleton alterations in non-alcoholic fatty liver disease
Authors: Pessoa, João
Teixeira, José
Keywords: Non-alcoholic fatty liver disease; Hepatocytes; Hepatic stellate cells; Cytoskeleton; α-Smooth muscle actin; Keratin 18
Issue Date: 30-Dec-2021
Publisher: Elsevier Inc.
Project: POCI-01-0145-FEDER-028147 
Serial title, monograph or event: Metabolism Clinical and Experimental
Issue: 128
Abstract: Background: Due to its extremely high prevalence and severity, non-alcoholic fatty liver disease (NALFD) is a serious health and economic concern worldwide. Developing effective methods of diagnosis and therapy demands a deep understanding of its molecular basis. One of the strategies in such an endeavor is the analysis of alterations in the morphology of liver cells. Such alterations, widely reported in NAFLD patients and disease models, are related to the cytoskeleton. Therefore, the fate of the cytoskeleton components is useful to uncover the molecular basis of NAFLD, to further design innovative approaches for its diagnosis and therapy. Main findings: Several cytoskeleton proteins are up-regulated in liver cells of NAFLD patients. Under pathological conditions, keratin 18 is released from hepatocytes and its detection in the blood emerges as a non-invasive diagnosis tool. α-Smooth muscle actin is up-regulated in hepatic stellate cells and its downregulation has been widely tested as a potential NALFD therapeutic approach. Other cytoskeleton proteins, such as vimentin, are also up-regulated. Conclusions: NAFLD progression involves alterations in expression levels of proteins that build the liver cytoskeleton or associate with it. These findings provide a timely opportunity of developing novel approaches for NAFLD diagnosis and therapy
ISSN: 0026-0495
DOI: 10.1016/j.metabol.2021.155115
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais

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