Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/96281
DC FieldValueLanguage
dc.contributor.authorFernandes, Ana R.-
dc.contributor.authorSanchez-Lopez, Elena-
dc.contributor.authorSantini, Antonello-
dc.contributor.authorSantos, Tiago dos-
dc.contributor.authorGarcia, Maria L.-
dc.contributor.authorSilva, Amélia Maria Lopes Dias da-
dc.contributor.authorSouto, Eliana B.-
dc.date.accessioned2021-11-05T17:20:09Z-
dc.date.available2021-11-05T17:20:09Z-
dc.date.issued2021-10-18-
dc.identifier.issn2079-4991pt
dc.identifier.urihttp://hdl.handle.net/10316/96281-
dc.description.abstractOil-in-water nanoemulsions (NEs) are considered a suitable nanotechnological approach to improve the eye-related bioavailability of lipophilic drugs. The potential of cationic NEs is prominent due to the electrostatic interaction that occurs between the positively charged droplets with the negatively charged mucins present in the tear film. This interaction offers prolonged NEs residence at the ocular surface, increasing the drug absorption. Triamcinolone acetonide (TA) is one of the first pharmacologic strategies applied as an intravitreal injection in the treatment of age-related macular degeneration (AMD). Newly synthesized quaternary derivatives of 1,4-diazabicyclo[2.2.2]octane (DABCO) and quinuclidine surfactants have been screened with the purpose to select the best compound to formulate long-term stable NEs that combine the best physicochemical properties for the loading of TA intended for ocular administration.pt
dc.language.isoengpt
dc.publisherMDPIpt
dc.relationSFRH/BD/130555/2017pt
dc.relationUIDB/04033/2020pt
dc.relationUIDB/04469/2020pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subjectDABCO surfactantspt
dc.subjectCationic nanoemulsionspt
dc.subjectOcular administrationpt
dc.subjectQuinuclidine surfactantspt
dc.subjectTriamcinolone acetonidept
dc.titleMono- and Dicationic DABCO/Quinuclidine Composed Nanomaterials for the Loading of Steroidal Drug: 32 Factorial Design and Physicochemical Characterizationpt
dc.typearticle-
degois.publication.firstPage2758pt
degois.publication.issue10pt
degois.publication.titleNanomaterialspt
dc.peerreviewedyespt
dc.identifier.doi10.3390/nano11102758pt
degois.publication.volume11pt
dc.date.embargo2021-10-18*
uc.date.periodoEmbargo0pt
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
crisitem.author.deptFaculty of Pharmacy-
crisitem.author.deptFaculty of Pharmacy-
crisitem.author.orcid0000-0002-8787-7854-
crisitem.author.orcid0000-0002-9737-6017-
Appears in Collections:FFUC- Artigos em Revistas Internacionais
Files in This Item:
File Description SizeFormat
nanomaterials-11-02758 (1).pdf7.73 MBAdobe PDFView/Open
Show simple item record

Page view(s)

9
checked on Dec 24, 2021

Download(s)

2
checked on Dec 24, 2021

Google ScholarTM

Check

Altmetric

Altmetric


This item is licensed under a Creative Commons License Creative Commons