Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/95932
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dc.contributor.authorMarkiewicz-Kijewska, Małgorzata-
dc.contributor.authorKaliciński, Piotr-
dc.contributor.authorTorres Canizales, Juan-
dc.contributor.authorDi Giorgio, Angelo-
dc.contributor.authorBaumann, Ulrich-
dc.contributor.authorJorns, Carl-
dc.contributor.authorBaker, Alastair-
dc.contributor.authorLopes, Maria Francelina-
dc.contributor.authorFrauca Remacha, Esteban-
dc.contributor.authorLopez-Granados, Eduardo-
dc.contributor.authorJara Vega, Paloma-
dc.contributor.authorBasso, Maria-Sole-
dc.contributor.authorKowalewski, Grzegorz-
dc.contributor.authorKamińska, Diana-
dc.contributor.authorFerreira, Sandra-
dc.contributor.authorLiccardo, Daniela-
dc.contributor.authorPietrobattista, Andrea-
dc.contributor.authorSpada, Marco-
dc.contributor.authorOn Behalf Of Ern TransplantChild Healthcare Working Group, null-
dc.date.accessioned2021-10-21T14:31:46Z-
dc.date.available2021-10-21T14:31:46Z-
dc.date.issued2021-08-31-
dc.identifier.issn2227-9067pt
dc.identifier.urihttps://hdl.handle.net/10316/95932-
dc.description.abstractAn increasing number of AB0-incompatible (AB0i) liver transplantations (LT) are being undertaken internationally in recent years due to organ shortages and the need for urgent transplantation. The aim of our study was establish the value of ABOi LT from available retrospective results of AB0i pediatric liver transplantations performed in European reference centers now belonging to the TransplantChild, European Reference Network (ERN). Data from medical records were analyzed, including demographic data, diagnosis, urgency of transplantation, time on the waiting list, PELD/MELD score, desensitization procedures, immunosuppression, selected post-transplant complications, and patient and graft survival. A total of 142 patients (pts) with transplants between 1986 and 2018 in 8 European transplant centers were included in the study. The indications for liver transplantation were: cholestatic diseases in 62 pts, acute liver failure in 42 pts, and other conditions in the remaining 38 pts. Sixty-six patients received grafts from living donors, and seventy-six received grafts from deceased donors. Both patient and graft survival were significantly affected by deceased donor type, urgent transplantation, and the development of vascular complications. In the multivariate analysis, vascular complications had a negative impact on patient and graft survival, while a longer time from the first AB0i LT in the study showed better results, suggesting an international learning experience. In conclusion, we believe that AB0i LT in children is now a safe procedure that may be adopted more readily in children.pt
dc.description.sponsorshipThis study was performed with the participation of centers of the European Reference Network on Pediatric Transplantation (ERN TransplantChild), which is partly cofounded by the European Union within the framework of the Third Health Programme ERN, specific agreement number 847103.pt
dc.language.isoengpt
dc.publisherMDPIpt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subjectAB0-incompatible liver transplantationpt
dc.subjectChildrenpt
dc.subjectComplicationspt
dc.subjectGraft survivalpt
dc.subjectImmunosuppressionpt
dc.subjectPatient survivalpt
dc.subjectRejectionpt
dc.titleABO Incompatible Liver Transplantation in Children: A 20 Year Experience from Centres in the TransplantChild European Reference Networkpt
dc.typearticle-
degois.publication.firstPage760pt
degois.publication.issue9pt
degois.publication.titleChildrenpt
dc.peerreviewedyespt
dc.identifier.doi10.3390/children8090760pt
degois.publication.volume8pt
dc.date.embargo2021-08-31*
uc.date.periodoEmbargo0pt
item.openairetypearticle-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextCom Texto completo-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
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