Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/95773
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dc.contributor.authorMunoz-Pinto, Mario F.-
dc.contributor.authorEmpadinhas, Nuno Miguel da Silva-
dc.contributor.authorCardoso, Sandra M.-
dc.date.accessioned2021-09-16T16:29:36Z-
dc.date.available2021-09-16T16:29:36Z-
dc.date.issued2021-
dc.identifier.issn15681637pt
dc.identifier.urihttps://hdl.handle.net/10316/95773-
dc.description.abstractRecent evidence confirms that PD is indeed a multifactorial disease with different aetiologies and prodromal symptomatology that likely depend on the initial trigger. New players with important roles as triggers, facilitators and aggravators of the PD neurodegenerative process have re-emerged in the last few years, the microbes. Having evolved in association with humans for ages, microbes and their products are now seen as fundamental regulators of human physiology with disturbances in their balance being increasingly accepted to have a relevant impact on the progression of disease in general and on PD in particular. In this review, we comprehensively address early studies that have directly or indirectly linked bacteria or other infectious agents to the onset and progression of PD, from the earliest suspects to the most recent culprits, the gut microbiota. The quest for effective treatments to arrest PD progression must inevitably address the different interactions between microbiota and human cells, and naturally consider the gut-brain axis. The comprehensive characterization of such mechanisms will help design innovative bacteriotherapeutic approaches to selectively shape the gut microbiota profile ultimately to halt PD progression. The present review describes our current understanding of the role of microorganisms and their endosymbiotic relatives, the mitochondria, in inducing, facilitating, or aggravating PD pathogenesis.pt
dc.language.isoengpt
dc.publisherElsevierpt
dc.relationPOCI-01–0145-FEDER-029221/POLYREP: Um polissacarídeo intrigante de micobactérias: reciclagem, replicação e aplicaçõespt
dc.relationPOCI-01−0145-FEDER-030712pt
dc.relationPTDC/BTM-TEC/29221/2017pt
dc.relationPTDC/MED-NEU/3644/2020/The Gut-Immune-Brain Axis in Parkinson diseasept
dc.relationUIDB/04539/2020pt
dc.relationCENTRO-01−0145-FEDER-000012/HealthyAging2020pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt
dc.subjectAge-related Parkinson’s diseasept
dc.subjectBacteriapt
dc.subjectGut microbiomept
dc.subjectGut-brain axispt
dc.subjectInfectionpt
dc.subjectInflammationpt
dc.subjectMitochondriapt
dc.subject.meshBrainpt
dc.subject.meshHumanspt
dc.subject.meshGastrointestinal Microbiomept
dc.subject.meshMicrobiotapt
dc.subject.meshParkinson Diseasept
dc.titleThe neuromicrobiology of Parkinson's disease: A unifying theorypt
dc.typearticle-
degois.publication.firstPage101396pt
degois.publication.titleAgeing Research Reviewspt
dc.peerreviewedyespt
dc.identifier.doi10.1016/j.arr.2021.101396pt
degois.publication.volume70pt
dc.date.embargo2021-01-01*
uc.date.periodoEmbargo0pt
item.openairetypearticle-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextCom Texto completo-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0001-8938-7560-
crisitem.author.orcid0000-0002-2199-0555-
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
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