Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/95483
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dc.contributor.authorOliveira, Gabriela L.-
dc.contributor.authorCoelho, Ana R.-
dc.contributor.authorMarques, Ricardo-
dc.contributor.authorOliveira, Paulo J.-
dc.date.accessioned2021-07-29T09:33:14Z-
dc.date.available2021-07-29T09:33:14Z-
dc.date.issued2021-
dc.identifier.issn09254439pt
dc.identifier.urihttp://hdl.handle.net/10316/95483-
dc.description.abstractTo adapt to tumoral environment conditions or even to escape chemotherapy, cells rapidly reprogram their metabolism to handle adversities and survive. Given the rapid rise of studies uncovering novel insights and therapeutic opportunities based on the role of mitochondria in tumor metabolic programing and therapeutics, this review summarizes most significant developments in the field. Taking in mind the key role of mitochondria on carcinogenesis and tumor progression due to their involvement on tumor plasticity, metabolic remodeling, and signaling re-wiring, those organelles are also potential therapeutic targets. Among other topics, we address the recent data intersecting mitochondria as of prognostic value and staging in cancer, by mitochondrial DNA (mtDNA) determination, and current inhibitors developments targeting mtDNA, OXPHOS machinery and metabolic pathways. We contribute for a holistic view of the role of mitochondria metabolism and directed therapeutics to understand tumor metabolism, to circumvent therapy resistance, and to control tumor development.pt
dc.description.sponsorshipGabriela L. Oliveira is supported by project “Summer Course in Interdisciplinary Research, Development and Innovation in Cellular and Molecular Metabolism” (15-20/7/245), funded by FCT and Directorate General for Higher Education (DGES).pt
dc.language.isoengpt
dc.relationPOCI-01-0145-FEDER-016390 [CANCEL STEM]pt
dc.relationinfo:eu-repo/grantAgreement/FCT/04539/2020pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt
dc.subjectCancerpt
dc.subjectMetabolic pathwayspt
dc.subjectMetabolismpt
dc.subjectMitochondriapt
dc.subjectmtDNApt
dc.subject.meshAntineoplastic Agentspt
dc.subject.meshDNA, Mitochondrialpt
dc.subject.meshDrug Resistance, Neoplasmpt
dc.subject.meshHumanspt
dc.subject.meshMitochondriapt
dc.subject.meshNeoplasm Stagingpt
dc.subject.meshNeoplasmspt
dc.subject.meshOxidative Phosphorylationpt
dc.subject.meshPrognosispt
dc.subject.meshSignal Transductionpt
dc.subject.meshTumor Microenvironmentpt
dc.subject.meshWarburg Effect, Oncologicpt
dc.titleCancer cell metabolism: Rewiring the mitochondrial hubpt
dc.typearticle-
degois.publication.firstPage166016pt
degois.publication.issue2pt
degois.publication.titleBBA - Molecular Basis of Diseasept
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0925443920303641pt
dc.peerreviewedyespt
dc.identifier.doi10.1016/j.bbadis.2020.166016pt
degois.publication.volume1867pt
dc.date.embargo2021-01-01*
uc.date.periodoEmbargo0pt
item.fulltextCom Texto completo-
item.languageiso639-1en-
item.grantfulltextopen-
crisitem.author.deptInstitute of Interdisciplinary Research-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0002-5201-9948-
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
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