Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/93443
DC Field | Value | Language |
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dc.contributor.author | Magalhães, R. | - |
dc.contributor.author | Soares, José Miguel | - |
dc.contributor.author | Conde, Raquel | - |
dc.contributor.author | Magalhães, Ricardo | - |
dc.contributor.author | Marques, Paulo | - |
dc.contributor.author | Magalhães, Rosana | - |
dc.contributor.author | Gomes, Luciana | - |
dc.contributor.author | Gonçalves, Óscar Filipe Coelho Neves | - |
dc.contributor.author | Arantes, Mavilde | - |
dc.contributor.author | Sampaio, Adriana | - |
dc.date.accessioned | 2021-03-16T16:41:32Z | - |
dc.date.available | 2021-03-16T16:41:32Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 1931-7557 | - |
dc.identifier.issn | 1931-7565 | - |
dc.identifier.uri | https://hdl.handle.net/10316/93443 | - |
dc.description.abstract | Functional connectivity (FC) is typically altered in individuals with Multiple Sclerosis (MS). However, in relapsing-remitting multiple sclerosis (RRMS) patients, the relationship between brain FC, tissue integrity and cognitive impairment is still unclear as contradictory findings have been documented. In this exploratory study we compared both the whole brain connectome and resting state networks (RSNs) FC of twenty-one RRMS and seventeen healthy controls (HCs), using combined network based statistics and independent component analyses. The total white matter (WM) lesion volume and information processing efficiency were also correlated with FC in the RRMS group. Both whole brain connectome and individual RSNs FC were diminished in patients with RRMS compared to HC. Additionally, the reduction in FC was found to be a function of the total WM lesion volume, with greatest impact in those harboring the largest lesion volume. Finally, a positive correlation between FC and information processing efficiency was observed in RRMS. This complimentary whole brain and RSNs FC approach can contribute to clarify literature inconsistencies regarding FC alterations and provide new insights on the white matter structural damage in explaining functional abnormalities in RRMS. | - |
dc.language.iso | eng | - |
dc.rights | openAccess | - |
dc.subject | Functional connectivity; Information processing efficiency; Multiple sclerosis; Resting State; White matter lesion | - |
dc.title | Alterations in functional connectivity are associated with white matter lesions and information processing efficiency in multiple sclerosis | - |
dc.type | article | - |
degois.publication.firstPage | 375 | - |
degois.publication.lastPage | 388 | - |
degois.publication.issue | 1 | - |
dc.peerreviewed | yes | - |
dc.identifier.doi | 10.1007/s11682-020-00264-z | - |
degois.publication.volume | 15 | - |
dc.date.embargo | 2021-01-01 | * |
uc.date.periodoEmbargo | 0 | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
crisitem.author.researchunit | Center for Research in Neuropsychology and Cognitive Behavioral Intervention | - |
crisitem.author.orcid | 0000-0003-2735-9155 | - |
crisitem.author.orcid | 0000-0001-7347-1282 | - |
Appears in Collections: | FPCEUC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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Alterations in functional connectivity are associated with whitematter lesions and information processing efficiency in multiple sclerosis.pdf | 6.69 MB | Unknown | View/Open |
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