Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/93421
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dc.contributor.authorJorge, Lília-
dc.contributor.authorMartins, Ricardo Filipe Alves-
dc.contributor.authorCanário, Nádia-
dc.contributor.authorXavier, Carolina-
dc.contributor.authorAbrunhosa, Antero José Pena Afonso de-
dc.contributor.authorSantana, Isabel-
dc.contributor.authorCastelo-Branco, Miguel-
dc.date.accessioned2021-03-11T15:57:20Z-
dc.date.available2021-03-11T15:57:20Z-
dc.date.issued2021-01-23-
dc.identifier.issn13872877pt
dc.identifier.issn18758908pt
dc.identifier.urihttp://hdl.handle.net/10316/93421-
dc.description.abstractBackground: It has been proposed that amyloid-β (Aβ) plays a causal role in Alzheimer’s disease (AD) by triggering a series of pathologic events—possibly including neuroinflammation—which culminate in progressive brain atrophy. However, the interplay between the two pathological molecular events and how both are associated with neurodegeneration is still unclear. Objective: We aimed to estimate the spatial inter-relationship between neurodegeneration, neuroinflammation and Aβ deposition in a cohort of 20 mild AD patients and 17 healthy controls (HC). Methods: We resorted to magnetic resonance imaging to measure cortical atrophy, using the radiotracer 11C-PK11195 PET to measure neuroinflammation levels and 11C-PiB PET to assess Aβ levels. Between-group comparisons were computed to explore AD-related changes in the three types of markers. To examine the effects of each one of the molecular pathologic mechanisms on neurodegeneration we computed: 1) ANCOVAs with the anatomic data, controlling for radiotracer uptake differences between groups and 2) voxel-based multiple regression analysis between-modalities. In addition, associations in anatomically defined regions of interests were also investigated. Results: We found significant differences between AD and controls in the levels of atrophy, neuroinflammation, and Aβ deposition. Associations between Aβ aggregation and brain atrophy were detected in AD in a widely distributed pattern, whereas associations between microglia activation and structural measures of neurodegeneration were restricted to few anatomically regions. Conclusion: In summary, Aβ deposition, as opposed to neuroinflammation, was more associated with cortical atrophy, suggesting a prominent role of Aβ in neurodegeneration at a mild stage of the AD.pt
dc.language.isoporpt
dc.rightsopenAccesspt
dc.subjectAlzheimer’s disease; amyloid-β; magnetic resonance imaging; neurodegeneration; neuroinflammation; positron emission tomographypt
dc.titleInvestigating the Spatial Associations Between Amyloid-β Deposition, Grey Matter Volume, and Neuroinflammation in Alzheimer's Diseasept
dc.typearticle-
degois.publication.firstPage113pt
degois.publication.lastPage132pt
degois.publication.issue1pt
degois.publication.titleJournal of Alzheimer's Diseasept
dc.relation.publisherversionhttp://doi.org/10.3233/JAD-200840pt
dc.peerreviewedyespt
dc.identifier.doi10.3233/JAD-200840pt
degois.publication.volume80pt
dc.date.embargo2021-01-23*
uc.date.periodoEmbargo0pt
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1pt-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCIBIT - Coimbra Institute for Biomedical Imaging and Translational Research-
crisitem.author.orcid0000-0001-7184-185X-
crisitem.author.orcid0000-0002-4145-854X-
crisitem.author.orcid0000-0003-4364-6373-
Appears in Collections:I&D ICNAS - Artigos em Revistas Internacionais
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