Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/93144
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Brandão, Pedro | - |
dc.contributor.author | Marques, Carolina | - |
dc.contributor.author | Burke, Anthony J. | - |
dc.contributor.author | Pineiro, Marta | - |
dc.date.accessioned | 2021-02-17T11:42:45Z | - |
dc.date.available | 2021-02-17T11:42:45Z | - |
dc.date.issued | 2021-02-05 | - |
dc.identifier.issn | 02235234 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/93144 | - |
dc.description.abstract | Oxindole derivatives are known for their great interest in the field of Medicinal Chemistry, as they display vast biological activities. Recent efforts concerning the preparation of oxindole derivatives using isatin-based multicomponent reactions (MCRs) constitute a great advance in generating druglike libraries fast and with wide scaffold diversity. In this review, we address those recent developments, exploring the synthetic pathways and biological activities described for these compounds, namely antitumor, antibacterial, antifungal, antiparasitic, antiviral, antioxidant, anti-inflammatory and central nervous system (CNS) pathologies. To add new depth to this work, we used a well-established web-based free tool (SwissADME) to evaluate the most promising scaffolds in what concerns their druglike properties, namely by evaluating their compliance with some of the most valuable rules applied by medicinal chemists in both academia and industrial settings (Lipinski, Ghose, Veber, Egan, Muegge). The aim of this review is to endorse isatin-based MCRs as a valuable synthetic approach to attain new hit compounds bearing the oxindole privileged structure, while critically exploring these scaffolds' druglike properties. | pt |
dc.language.iso | eng | pt |
dc.publisher | Elsevier Masson | pt |
dc.relation | PD/BD/128490/2017 | pt |
dc.relation | UIDB/00313/2020 | pt |
dc.relation | UIDB/50006/2020 | pt |
dc.rights | embargoedAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt |
dc.subject | Bioactive compounds | pt |
dc.subject | Isatin | pt |
dc.subject | Multicomponent reactions | pt |
dc.subject | Oxindole | pt |
dc.title | The application of isatin-based multicomponent-reactions in the quest for new bioactive and druglike molecules | pt |
dc.type | article | - |
degois.publication.firstPage | 113102 | pt |
degois.publication.title | European Journal of Medicinal Chemistry | pt |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0223523420310746 | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1016/j.ejmech.2020.113102 | pt |
degois.publication.volume | 211 | pt |
dc.date.embargo | 2023-02-05 | * |
uc.date.periodoEmbargo | 730 | pt |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0002-1455-7470 | - |
crisitem.author.orcid | 0000-0002-7460-3758 | - |
Appears in Collections: | I&D CQC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Brandao2020EurJMedChem.pdf | 6.92 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
70
checked on Apr 22, 2024
WEB OF SCIENCETM
Citations
65
checked on Apr 2, 2024
Page view(s)
130
checked on Apr 23, 2024
Download(s)
51
checked on Apr 23, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License