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Title: Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine
Authors: Ferreira, Raquel
Napoli, Joseph
Enver, Tariq
Bernardino, Liliana
Ferreira, Lino
Issue Date: 26-Aug-2020
Publisher: Nature
Project: ERA Chair project (ERA@UC, ref:669088) through EU Horizon 2020 618 program 
POCI-01-0145-FEDER-016390 (acronym: CANCEL STEM) and POCI-01-0145- 619 FEDER-029414 (acronym: LIghtBRARY) projects through Compete 2020 and FCT programs 
2IQBIONEURO (reference: 0624_2IQBIONEURO_6_E) and 621 NEUROATLANTIC (reference: EAPA_791/2018) co-funded by INTERREG (Atlantic program or 622 V-A Spain-Portugal) and European fund for Regional Development (FEDER), 
FCT (Portugal, 623 SFRH/BPD/102103/2014), National Funds by Foundation for Science and Technology 624 (UID/Multi/00709/2013), “Programa Operacional do Centro, Centro 2020” through the funding of 625 the ICON project (Interdisciplinary Challenges On Neurodegeneration; CENTRO-01-0145- 626 FEDER-000013), EXPL/BIM-MED/0822/2013 (LB), (SFRH/BPD/94228/2013, IF/00178/2015) 627 (RF), 
Cerebrovascular Disease Grant and L’Oréal-UNESCO Portugal for Women in Science 
Serial title, monograph or event: Nature Communications
Volume: 11
Abstract: Retinoids regulate a wide spectrum of cellular functions from the embryo throughout adulthood, including cell differentiation, metabolic regulation, and inflammation. These traits make retinoids very attractive molecules for medical purposes. In light of some of the physicochemical limitations of retinoids, the development of drug delivery systems offers several advantages for clinical translation of retinoid-based therapies, including improved solubilization, prolonged circulation, reduced toxicity, sustained release, and improved efficacy. In this Review, we discuss advances in preclinical and clinical tests regarding retinoid formulations, specifically the ones based in natural retinoids, evaluated in the context of regenerative medicine, brain, cancer, skin, and immune diseases. Advantages and limitations of retinoid formulations, as well as prospects to push the field forward, will be presented.
DOI: 10.1038/s41467-020-18042-2
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais

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