Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/92395
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pitrez, Patrícia R. | - |
dc.contributor.author | Aires, Helena R. | - |
dc.contributor.author | Tomé, Inês | - |
dc.contributor.author | Ferreira, Rita Sá | - |
dc.contributor.author | Ferreira, Lino | - |
dc.date.accessioned | 2021-01-02T15:26:26Z | - |
dc.date.available | 2021-01-02T15:26:26Z | - |
dc.date.issued | 2018 | - |
dc.identifier.isbn | 978-3-319-99318-8 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/92395 | - |
dc.description.abstract | Aging is a risk factor for cardiovascular diseases. Through aging, blood vessels become stiffer, less elastic and, thus, with less ability to contract. The objectives of this chapter are to review (i) recent progresses in the characterization of physiological and pathological vascular aging and (ii) in vitro platforms to study vascular aging. Initially, we will discuss the causes and biomarkers of vascular aging. Then we will discuss the main characteristics related to physiological and pathological aging including (i) altered ECM remodeling (e.g. composition, mechanical properties, degradation, calcification of the ECM during aging), (ii) enhanced fibrosis (e.g. causes and mechanisms), (iii) vascular cell dysfunction triggered by chronic oxidative stress, inflammation or senescence, and (iv) altered responses of vascular cells to flow shear stress. Finally, we will discuss in vitro systems to study vascular aging, particularly the effect of biomechanics in aged cells as well as the effect of drugs during vascular aging. | pt |
dc.language.iso | eng | pt |
dc.publisher | Springer | pt |
dc.rights | openAccess | pt |
dc.title | Physiological and Pathological Vascular Aging | pt |
dc.type | book | pt |
degois.publication.firstPage | 51 | pt |
degois.publication.lastPage | 72 | pt |
degois.publication.title | Biophysical Regulation of Vascular Differentiation and Assembly | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1007/978-3-319-99319-5_3 | pt |
dc.date.embargo | 2018-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.openairecristype | http://purl.org/coar/resource_type/c_2f33 | - |
item.openairetype | book | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-3116-0723 | - |
crisitem.author.orcid | 0000-0001-8985-9302 | - |
Appears in Collections: | I&D CNC - Capítulos (ou partes) de Livros |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Pitrez et al Book Chapter.pdf | 1.13 MB | Adobe PDF | View/Open |
WEB OF SCIENCETM
Citations
1
checked on Mar 2, 2024
Page view(s)
321
checked on Apr 23, 2024
Download(s)
350
checked on Apr 23, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.