Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/90810
DC FieldValueLanguage
dc.contributor.authorMendes, Maria-
dc.contributor.authorBasso, João-
dc.contributor.authorSilva, Jessica-
dc.contributor.authorCova, Tânia-
dc.contributor.authorSousa, João-
dc.contributor.authorPais, Alberto-
dc.contributor.authorVitorino, Carla-
dc.date.accessioned2020-09-08T13:55:16Z-
dc.date.available2020-09-08T13:55:16Z-
dc.date.issued2020-09-25-
dc.identifier.issn03785173pt
dc.identifier.urihttps://hdl.handle.net/10316/90810-
dc.description.abstractUltra-small nanostructured lipid carriers (usNLCs) are stable, biocompatible and biodegradable colloidal systems, claiming a broad set of advanced features suitable for cancer drug delivery. To unleash their potential in glioblastoma research and therapy, we have developed an usNLC prototype able to co-encapsulate atorvastatin calcium and curcumin, as repurposed drugs previously screened from molecular dynamics simulations. The novelty not only relies on the drug repositioning approach, but also on a robust computational methodology utilized for formulation optimization, under the umbrella of multivariate analysis and full factorial designs. A coating procedure with red blood cell membranes is ultimately hypothesized, aiming at integrating the biomimetic concept into usNLCs for glioblastoma therapeutics. The formulation composition and process parameters, that demonstrated a high-risk level for the final quality and performance of the usNLCs, include the solid:liquid lipid ratio, type and concentration of liquid lipids and surfactants, along with the type of production method. Particles with an average diameter of ca. 50 nm, and a polydispersity index lower than 0.3 were produced, exhibiting high stability, up-scalability, drug protection and sustained co-release properties, meeting the suitable critical quality attributes for intravenous administration. Also, a Taguchi design was successfully applied to optimizing usNLCs as cell membrane-coating technology.pt
dc.language.isoengpt
dc.publisherElsevierpt
dc.relationPOCI-01-0145-FEDER- 016648pt
dc.relationUID/NEU/04539/ 2013-2020pt
dc.relationPOCI-01-0145-FEDER-007440pt
dc.relationUID/QUI/00313/202pt
dc.relationFRH/BD/133996/2017pt
dc.relationSFRH/BD/149138/2019pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subjectBiomimetingpt
dc.subjectDesign of experimentspt
dc.subjectDrug repurposingpt
dc.subjectGlioblastomapt
dc.subjectProcess parameterspt
dc.subjectUltra-small nanostructured lipid carrierspt
dc.titleBiomimeting ultra-small lipid nanoconstructs for glioblastoma treatment: A computationally guided experimental approachpt
dc.typearticle-
degois.publication.firstPage1pt
degois.publication.lastPage20pt
degois.publication.issue119661pt
degois.publication.titleInternational Journal of Pharmaceuticspt
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0378517320306451pt
dc.peerreviewedyespt
dc.identifier.doi10.1016/j.ijpharm.2020.119661pt
degois.publication.volume587pt
dc.date.embargo2020-09-25*
uc.date.periodoEmbargo0pt
item.openairetypearticle-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextCom Texto completo-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.orcid0000-0003-3696-4517-
crisitem.author.orcid0000-0003-3212-7324-
crisitem.author.orcid0000-0002-2840-6091-
crisitem.author.orcid0000-0002-6725-6460-
crisitem.author.orcid0000-0003-3424-548X-
Appears in Collections:I&D CQC - Artigos em Revistas Internacionais
Files in This Item:
File Description SizeFormat
IJP.pdf4.61 MBAdobe PDFView/Open
Show simple item record

SCOPUSTM   
Citations

6
checked on Nov 9, 2022

WEB OF SCIENCETM
Citations 10

7
checked on May 2, 2023

Page view(s)

172
checked on Mar 26, 2024

Download(s)

359
checked on Mar 26, 2024

Google ScholarTM

Check

Altmetric

Altmetric


This item is licensed under a Creative Commons License Creative Commons