Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/90810
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mendes, Maria | - |
dc.contributor.author | Basso, João | - |
dc.contributor.author | Silva, Jessica | - |
dc.contributor.author | Cova, Tânia | - |
dc.contributor.author | Sousa, João | - |
dc.contributor.author | Pais, Alberto | - |
dc.contributor.author | Vitorino, Carla | - |
dc.date.accessioned | 2020-09-08T13:55:16Z | - |
dc.date.available | 2020-09-08T13:55:16Z | - |
dc.date.issued | 2020-09-25 | - |
dc.identifier.issn | 03785173 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/90810 | - |
dc.description.abstract | Ultra-small nanostructured lipid carriers (usNLCs) are stable, biocompatible and biodegradable colloidal systems, claiming a broad set of advanced features suitable for cancer drug delivery. To unleash their potential in glioblastoma research and therapy, we have developed an usNLC prototype able to co-encapsulate atorvastatin calcium and curcumin, as repurposed drugs previously screened from molecular dynamics simulations. The novelty not only relies on the drug repositioning approach, but also on a robust computational methodology utilized for formulation optimization, under the umbrella of multivariate analysis and full factorial designs. A coating procedure with red blood cell membranes is ultimately hypothesized, aiming at integrating the biomimetic concept into usNLCs for glioblastoma therapeutics. The formulation composition and process parameters, that demonstrated a high-risk level for the final quality and performance of the usNLCs, include the solid:liquid lipid ratio, type and concentration of liquid lipids and surfactants, along with the type of production method. Particles with an average diameter of ca. 50 nm, and a polydispersity index lower than 0.3 were produced, exhibiting high stability, up-scalability, drug protection and sustained co-release properties, meeting the suitable critical quality attributes for intravenous administration. Also, a Taguchi design was successfully applied to optimizing usNLCs as cell membrane-coating technology. | pt |
dc.language.iso | eng | pt |
dc.publisher | Elsevier | pt |
dc.relation | POCI-01-0145-FEDER- 016648 | pt |
dc.relation | UID/NEU/04539/ 2013-2020 | pt |
dc.relation | POCI-01-0145-FEDER-007440 | pt |
dc.relation | UID/QUI/00313/202 | pt |
dc.relation | FRH/BD/133996/2017 | pt |
dc.relation | SFRH/BD/149138/2019 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Biomimeting | pt |
dc.subject | Design of experiments | pt |
dc.subject | Drug repurposing | pt |
dc.subject | Glioblastoma | pt |
dc.subject | Process parameters | pt |
dc.subject | Ultra-small nanostructured lipid carriers | pt |
dc.title | Biomimeting ultra-small lipid nanoconstructs for glioblastoma treatment: A computationally guided experimental approach | pt |
dc.type | article | - |
degois.publication.firstPage | 1 | pt |
degois.publication.lastPage | 20 | pt |
degois.publication.issue | 119661 | pt |
degois.publication.title | International Journal of Pharmaceutics | pt |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0378517320306451 | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1016/j.ijpharm.2020.119661 | pt |
degois.publication.volume | 587 | pt |
dc.date.embargo | 2020-09-25 | * |
uc.date.periodoEmbargo | 0 | pt |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0003-3696-4517 | - |
crisitem.author.orcid | 0000-0003-3212-7324 | - |
crisitem.author.orcid | 0000-0002-2840-6091 | - |
crisitem.author.orcid | 0000-0002-6725-6460 | - |
crisitem.author.orcid | 0000-0003-3424-548X | - |
Appears in Collections: | I&D CQC - Artigos em Revistas Internacionais |
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