Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/90810
Título: | Biomimeting ultra-small lipid nanoconstructs for glioblastoma treatment: A computationally guided experimental approach | Autor: | Mendes, Maria Basso, João Silva, Jessica Cova, Tânia Sousa, João Pais, Alberto Vitorino, Carla |
Palavras-chave: | Biomimeting; Design of experiments; Drug repurposing; Glioblastoma; Process parameters; Ultra-small nanostructured lipid carriers | Data: | 25-Set-2020 | Editora: | Elsevier | Projeto: | POCI-01-0145-FEDER- 016648 UID/NEU/04539/ 2013-2020 POCI-01-0145-FEDER-007440 UID/QUI/00313/202 FRH/BD/133996/2017 SFRH/BD/149138/2019 |
Título da revista, periódico, livro ou evento: | International Journal of Pharmaceutics | Volume: | 587 | Número: | 119661 | Resumo: | Ultra-small nanostructured lipid carriers (usNLCs) are stable, biocompatible and biodegradable colloidal systems, claiming a broad set of advanced features suitable for cancer drug delivery. To unleash their potential in glioblastoma research and therapy, we have developed an usNLC prototype able to co-encapsulate atorvastatin calcium and curcumin, as repurposed drugs previously screened from molecular dynamics simulations. The novelty not only relies on the drug repositioning approach, but also on a robust computational methodology utilized for formulation optimization, under the umbrella of multivariate analysis and full factorial designs. A coating procedure with red blood cell membranes is ultimately hypothesized, aiming at integrating the biomimetic concept into usNLCs for glioblastoma therapeutics. The formulation composition and process parameters, that demonstrated a high-risk level for the final quality and performance of the usNLCs, include the solid:liquid lipid ratio, type and concentration of liquid lipids and surfactants, along with the type of production method. Particles with an average diameter of ca. 50 nm, and a polydispersity index lower than 0.3 were produced, exhibiting high stability, up-scalability, drug protection and sustained co-release properties, meeting the suitable critical quality attributes for intravenous administration. Also, a Taguchi design was successfully applied to optimizing usNLCs as cell membrane-coating technology. | URI: | https://hdl.handle.net/10316/90810 | ISSN: | 03785173 | DOI: | 10.1016/j.ijpharm.2020.119661 | Direitos: | openAccess |
Aparece nas coleções: | I&D CQC - Artigos em Revistas Internacionais |
Mostrar registo em formato completo
Citações SCOPUSTM
6
Visto em 9/nov/2022
Citações WEB OF SCIENCETM
10
7
Visto em 2/mai/2023
Visualizações de página
179
Visto em 24/abr/2024
Downloads
370
Visto em 24/abr/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Este registo está protegido por Licença Creative Commons