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Title: Ocular Risk Factors for Exudative AMD: A Novel Semiautomated Grading System
Authors: Marques, João Pedro
Costa, Miguel
Melo, Pedro
Oliveira, Carlos Manta 
Pires, Isabel
Cachulo, Maria Luz
Figueira, João
Silva, Rufino 
Issue Date: 2013
Publisher: Hindawi
Serial title, monograph or event: ISRN Ophthalmology
Volume: 2013
Abstract: Purpose. To evaluate the contribution of the ocular risk factors in the conversion of the fellow eye of patients with unilateral exudative AMD, using a novel semiautomated grading system. Materials and Methods. Single-center, retrospective study including 89 consecutive patients with unilateral exudative AMD and ≥3 years of followup. Baseline color fundus photographs were graded using an innovative grading software, RetmarkerAMD (Critical Health SA). Results. The follow-up period was 60.9 ± 31.3 months. The occurrence of CNV was confirmed in 42 eyes (47.2%). The cumulative incidence of CNV was 23.6% at 2 years, 33.7% at 3 years, 39.3% at 5 years, and 47.2% at 10 years, with a mean annual incidence of 12.0% (95% CI = 0.088-0.162). The absolute number of drusen in the central 1000 and 3000  μ m (P < 0.05) and the absolute number of drusen ≥125 µm in the central 3000 and 6000 µm (P < 0.05) proved to be significant risk factors for CNV. Conclusion. The use of quantitative variables in the determination of the OR of developing CNV allowed the establishment of significant risk factors for neovascularization. The long follow-up period and the innovative methodology reinforce the value of our results. This trial is registered with NCT00801541.
ISSN: 2090-5688
DOI: 10.1155/2013/464218
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

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