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Title: Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead
Authors: Boia, Raquel
Ruzafa, Noelia
Aires, Inês Dinis
Pereiro, Xandra
Ambrósio, António Francisco
Vecino, Elena
Santiago, Ana Raquel
Keywords: retinal ganglion cells; neurodegeneration; axonal regeneration; neuroprotection; optic neuropathies
Issue Date: 25-Mar-2020
Publisher: MDPI
Project: Portuguese Foundation for Science and Technology 
European Union (EU) 
Centro 2020 Regional Operational Programme 
Grupo UPV/EHU 
Grupo PUE 
Serial title, monograph or event: International Journal of Molecular Sciences
Volume: 21
Issue: 7
Place of publication or event: ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
Abstract: The retinal ganglion cells (RGCs) are the output cells of the retina into the brain. In mammals, these cells are not able to regenerate their axons after optic nerve injury, leaving the patients with optic neuropathies with permanent visual loss. An effective RGCs-directed therapy could provide a beneficial effect to prevent the progression of the disease. Axonal injury leads to the functional loss of RGCs and subsequently induces neuronal death, and axonal regeneration would be essential to restore the neuronal connectivity, and to reestablish the function of the visual system. The manipulation of several intrinsic and extrinsic factors has been proposed in order to stimulate axonal regeneration and functional repairing of axonal connections in the visual pathway. However, there is a missing point in the process since, until now, there is no therapeutic strategy directed to promote axonal regeneration of RGCs as a therapeutic approach for optic neuropathies.
ISSN: 1422-0067
DOI: 10.3390/ijms21072262
Rights: openAccess
Appears in Collections:I&D IBILI - Artigos em Revistas Internacionais

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