Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/8373
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dc.contributor.authorSalgueiro, Lígia Ribeiro-
dc.contributor.authorPinto, Eugénia-
dc.contributor.authorGonçalves, Maria José-
dc.contributor.authorCosta, Inês-
dc.contributor.authorPalmeira, Ana-
dc.contributor.authorCavaleiro, Carlos-
dc.contributor.authorPina-Vaz, Cidália-
dc.contributor.authorRodrigues, Acácio Gonçalves-
dc.contributor.authorMartinez-de-Oliveira, José-
dc.date.accessioned2009-02-09T14:51:19Z-
dc.date.available2009-02-09T14:51:19Z-
dc.date.issued2006en_US
dc.identifier.citationFlavour and Fragrance Journal. 21:5 (2006) 749-753en_US
dc.identifier.urihttp://hdl.handle.net/10316/8373-
dc.description.abstractThe antifungal activity of Thymus capitellatus oils on Candida, Aspergillus and dermatophyte strains were studied. The essential oils were obtained from the aerial parts of the plants by water distillation and analysed by GC and GC-MS. Three chemotypes were characterized: 1,8-cineole (47.5%), 1,8-cineole/borneol (28.8% and 19.5%, respectively) and 1,8-cineole/linalyl acetate/linalool (27.5%, 20.0% and 17.0%, respectively). The minimal inhibitory concentration (MIC) determined according to the NCCLS protocols (M27-A and M38-P) and the minimal lethal concentration (MLC) were used to evaluate the antifungal activity of the oils against Candida (seven clinical isolates and three ATCC type strains), Aspergillus (five clinical isolates, two CECT and two ATCC type strains) and five dermatophyte clinical fungi strains. The oils exhibited antifungal activity for the dermatophyte strains, with MIC values of 0.32-1.25 µl/ml; the chemotype 1,8-cineole/linalyl acetate/linalool proved to be more active. The highest antifungal activity of this oil can be associated with the contribution of the linalyl acetate. In the other hand, all samples showed low activity against Candida and Aspergillus strains. Copyright © 2006 John Wiley & Sons, Ltd.en_US
dc.language.isoengeng
dc.rightsopenAccesseng
dc.titleAntifungal activity of the essential oil of Thymus capitellatus against Candida, Aspergillus and dermatophyte strainsen_US
dc.typearticleen_US
dc.identifier.doi10.1002/ffj.1610en_US
uc.controloAutoridadeSim-
item.grantfulltextopen-
item.languageiso639-1en-
item.fulltextCom Texto completo-
crisitem.author.deptFaculty of Pharmacy-
crisitem.author.deptFaculty of Pharmacy-
crisitem.author.deptFaculty of Pharmacy-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0003-0948-821X-
crisitem.author.orcid0000-0003-4852-8982-
crisitem.author.orcid0000-0002-5937-1127-
Appears in Collections:FFUC- Artigos em Revistas Internacionais
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