Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/8340
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dc.contributor.authorFernandes, Maria A. S.-
dc.contributor.authorSantos, Maria S.-
dc.contributor.authorMoreno, António J. M.-
dc.contributor.authorDuburs, Gunars-
dc.contributor.authorOliveira, Catarina R.-
dc.contributor.authorVicente, Joaquim A. F.-
dc.date.accessioned2009-02-09T14:33:24Z-
dc.date.available2009-02-09T14:33:24Z-
dc.date.issued2004en_US
dc.identifier.citationJournal of Biochemical and Molecular Toxicology. 18:3 (2004) 162-169en_US
dc.identifier.urihttp://hdl.handle.net/10316/8340-
dc.description.abstractThe interference of glibenclamide, an antidiabetic sulfonylurea, with mitochondrial bioenergetics was assessed on mitochondrial ion fluxes (H+, K+, and Cl-) by passive osmotic swelling of rat liver mitochondria in K-acetate, KNO3, and KCl media, by O2 consumption, and by mitochondrial transmembrane potential (Deltapsi). Glibenclamide did not permeabilize the inner mitochondrial membrane to H+, but induced permeabilization to Cl- by opening the inner mitochondrial anion channel (IMAC). Cl- influx induced by glibenclamide facilitates K+ entry into mitochondria, thus promoting a net Cl-/K+ cotransport, Deltapsi dissipation, and stimulation of state 4 respiration rate. It was concluded that glibenclamide interferes with mitochondrial bioenergetics of rat liver by permeabilizing the inner mitochondrial membrane to Cl- and promoting a net Cl-/K+ cotransport inside mitochondria, without significant changes on membrane permeabilization to H+. © 2004 Wiley Periodicals, Inc. J Biochem Mol Toxicol 18:162-169, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.20022en_US
dc.language.isoengeng
dc.rightsopenAccesseng
dc.titleGlibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeabilityen_US
dc.typearticleen_US
dc.identifier.doi10.1002/jbt.20022en_US
uc.controloAutoridadeSim-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Medicine-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitMARE - Marine and Environmental Sciences Centre-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0002-6881-9392-
crisitem.author.orcid0000-0003-3575-7604-
crisitem.author.orcid0000-0001-6942-4328-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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