Voltammetric Behavior of Antileukemia Drug Glivec. Part I - Electrochemical Study of Glivec

Abstract

The electrochemical behavior of the antileukemia drug glivec was investigated at a glassy carbon electrode (GCE). The oxidation is a complex, pH-dependent, irreversible electrode process involving the transfer of 2 electrons and 2 protons and the formation of an electroactive product, Pglivec, which strongly adsorbs on the GCE surface and undergoes reversible oxidation. The adsorption of Pglivec at the GCE surface yields a compact monolayer that inhibits further oxidation of glivec. The electrochemical reduction is a simple pH dependent irreversible process involving the transfer of 2 electrons and 2 protons and occurs with the formation of a nonelectroactive product. The diffusion coefficient of glivec was calculated to be DO=7.35×10-6 cm2 s-1 in pH 4.5 0.1 M acetate buffer.