Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/80195
DC FieldValueLanguage
dc.contributor.authorMatos, M. B. C. de-
dc.contributor.authorPiedade, A. P.-
dc.contributor.authorAlvarez-Lorenzo, C-
dc.contributor.authorConcheiro, A.-
dc.contributor.authorBraga, M. E. M.-
dc.contributor.authorSousa, H. C. de-
dc.date.accessioned2018-07-16T10:01:20Z-
dc.date.available2018-07-16T10:01:20Z-
dc.date.issued2013-11-18-
dc.identifier.urihttp://hdl.handle.net/10316/80195-
dc.description.abstractA supercritical carbon dioxide (scCO2)-assisted foaming/mixing method (SFM) was implemented for preparing dexamethasone (DXMT)-loaded poly(ε-caprolactone)/silica nanoparticles (PCL/SNPs) composite materials suitable for bone regeneration. The composites were prepared from PCL and mesoporous SNPs (MCM-41/SBA-15) by means of scCO2-assisted SFM at several operational pressures, processing times and depressurization conditions. DXMT was loaded into SNPs (applying a scCO2 solvent impregnation/deposition method - SSID) and into PCL/SNPs composites (using the SFM method). The effects of the employed operational and compositional variables on the physicochemical and morphological features as well as in the in vitro release profiles of DXMT were analyzed in detail. This work demonstrates that the above-referred scCO2-based methods can be very useful for the preparation of DXMT-loaded PCL/SNPs composites with tunable physicochemical, thermomechanical, morphological and drug release properties and suitable for hard-tissue regeneration applications.pt
dc.language.isoengpt
dc.rightsopenAccesspt
dc.titleDexamethasone-loaded poly(ε-caprolactone)/silica nanoparticles composites prepared by supercritical CO2 foaming/mixing and depositionpt
dc.typearticle-
dc.peerreviewedyespt
dc.identifier.doi10.1016/j.ijpharm.2013.08.042pt
dc.date.embargo2013-11-18*
dc.date.periodoembargo0pt
uc.controloAutoridadeSim-
item.fulltextCom Texto completo-
item.languageiso639-1en-
item.grantfulltextopen-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCEMMPRE - Centre for Mechanical Engineering, Materials and Processes-
crisitem.author.researchunitCIEPQPF – Chemical Process Engineering and Forest Products Research Centre-
crisitem.author.researchunitCIEPQPF – Chemical Process Engineering and Forest Products Research Centre-
crisitem.author.orcid0000-0002-1588-0640-
crisitem.author.orcid0000-0003-4142-4021-
crisitem.author.orcid0000-0002-2629-7805-
Appears in Collections:I&D CIEPQPF - Artigos em Revistas Internacionais
Files in This Item:
File Description SizeFormat
1-s2.0-S0378517313007758-main.pdf2.45 MBAdobe PDFView/Open
Show simple item record

SCOPUSTM   
Citations

30
checked on May 29, 2020

WEB OF SCIENCETM
Citations 5

29
checked on Oct 2, 2021

Page view(s)

242
checked on Oct 15, 2021

Download(s) 50

301
checked on Oct 15, 2021

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.