Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/7852
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oliveira, Paulo | - |
dc.contributor.author | Rolo, Anabela | - |
dc.contributor.author | Seiça, R. | - |
dc.contributor.author | Palmeira, Carlos | - |
dc.contributor.author | Santos, M. S. | - |
dc.contributor.author | Moreno, António | - |
dc.date.accessioned | 2009-02-17T10:35:43Z | - |
dc.date.available | 2009-02-17T10:35:43Z | - |
dc.date.issued | 2001 | en_US |
dc.identifier.citation | Bioscience Reports. 21:1 (2001) 55-62 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/7852 | - |
dc.description.abstract | Type 2 diabetes (or non-insulin dependent diabetes mellitus, NIDDM) is a common metabolic disease in man. The Goto–Kakizaki (GK) rat has been designed as a NIDDM model. Previous studies with this strain have shown differences at the mitochondrial level. The mitochondrial permeability transition (MPT) is a widely studied phenomenon but yet poorly understood, that leads to mitochondrial dysfunction and cell death. The aim of this work was to compare the differences in susceptibility of induction of the MPT with calcium phosphate in GK and Wistar rats. Our results show that heart mitochondria from GK rats are less susceptible to the induction of MPT, and show a larger calcium accumulation before the overall loss of mitochondrial impermeability. | en_US |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.title | Decreased Susceptibility of Heart Mitochondria from Diabetic GK Rats to Mitochondrial Permeability Transition Induced by Calcium Phosphate | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1023/A:1010482017540 | en_US |
uc.controloAutoridade | Sim | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Faculty of Sciences and Technology | - |
crisitem.author.parentdept | University of Coimbra | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | MARE - Marine and Environmental Sciences Centre | - |
crisitem.author.orcid | 0000-0002-5201-9948 | - |
crisitem.author.orcid | 0000-0003-3535-9630 | - |
crisitem.author.orcid | 0000-0002-8378-0895 | - |
crisitem.author.orcid | 0000-0002-2639-7697 | - |
crisitem.author.orcid | 0000-0002-6881-9392 | - |
crisitem.author.orcid | 0000-0003-3575-7604 | - |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
SCOPUSTM
Citations
3
checked on May 1, 2023
Page view(s)
347
checked on Apr 23, 2024
Download(s)
250
checked on Apr 23, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.