Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/7824
Title: | Bile acids are toxic for isolated cardiac mitochondria | Authors: | Ferreira, Manuela Coxito, Pedro Sardão, Vilma Palmeira, Carlos Oliveira, Paulo |
Issue Date: | 2005 | Citation: | Cardiovascular Toxicology. 5:1 (2005) 63-73 | Abstract: | Cholestasis and other liver diseases may affect the heart through the toxic effects of the retained bile acids on cardiac mitochondria, which could explain the origin of hepatic-derived cardiomyopathies. The objective of this work was to test the hypothesis that bile acids are toxic to heart mitochondria for concentrations that are relevant for cholestasis. Heart mitochondria were isolated from rat and subjected to incubation with selected bile acids (litocholic acid [LCA], deoxycholic acid [DCA], chenodeoxycholic acid [CDCA], glycochenodeoxycholic acid [GCDC], taurodeoxycholic acid [CDCA], and glycoursodeoxycholic acid [GUDC]). We observed that the most toxic bile acids were also the most lipophilic ones (LCA, DCA, and CDCA), inducing a decrease on state 3 respiration, respiratory control ratio, and membrane potential and causing the induction of the mitochondrial permeability transition. GUDC was the bile acid with lower indexes of toxicity on isolated heart mitochondria. The results of this research indicate that attoxicologically relevant concentrations, most bile acids (mainly the most lipophilic) alter mitochondrial bioenergetics. The impairment of cardiac mitochondrial function may be an important cause for the observed cardiac alterations during cholestasis. | URI: | https://hdl.handle.net/10316/7824 | DOI: | 10.1385/CT:5:1:063 | Rights: | openAccess |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
Show full item record
WEB OF SCIENCETM
Citations
5
37
checked on Nov 2, 2024
Page view(s) 50
681
checked on Oct 29, 2024
Download(s)
300
checked on Oct 29, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.