Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/5847
Title: Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
Authors: Moreira, Vânia M. A. 
Vasaitis, Tadas S. 
Njar, Vincent C. O. 
Salvador, Jorge A. R. 
Keywords: Indazole; Prostate cancer; Androgen receptor; PC cell lines
Issue Date: 2007
Citation: Steroids. 72:14 (2007) 939-948
Abstract: A series of novel 1H- and 2H-indazole derivatives of the commercially available dehydroepiandrosterone acetate have been synthesized and tested for inhibition of human cytochrome 17[alpha]-hydroxylase-C17,20-lyase (CYP17), androgen receptor (AR) binding affinity, and cytotoxic potential against three prostate cancer (PC) cell lines.
URI: http://hdl.handle.net/10316/5847
DOI: 10.1016/j.steroids.2007.08.004
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
filec541629a68be4cf3a0f14468ca6566b8.pdf608.88 kBAdobe PDFView/Open
Show full item record

Page view(s) 50

509
checked on Nov 26, 2020

Download(s) 50

353
checked on Nov 26, 2020

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.