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https://hdl.handle.net/10316/5813| Title: | Enthalpy of solution of terfenadine in ethanol/water mixtures | Authors: | Canotilho, João Costa, Felisbela S. Sousa, Adriano T. Redinha, J. Simões Leitão, M. Luísa P. |
Keywords: | Crystal design; Crystallization; Polymorphism; Solubility; Solute self-aggregation; Solution enthalpy; Terfenadine | Issue Date: | 2000 | Citation: | Thermochimica Acta. 344:1-2 (2000) 9-13 | Abstract: | The enthalpy of solution of terfenadine in ethanol/water mixtures, 0-20.5 wt.% of water was determined by calorimetry. A Sudden increase of 1-2 kJ mol-1 in the enthalpy at a concentration value around 0.01 mol kg-1 is observed. This step in the enthalpy is interpreted as due to solute n-mer aggregates formation. The solubility of terfenadine in the cosolvent systems used in the calorimetric studies was determined. | URI: | https://hdl.handle.net/10316/5813 | DOI: | 10.1016/s0040-6031(99)00319-6 | Rights: | openAccess |
| Appears in Collections: | FFUC- Artigos em Revistas Internacionais |
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| fileed05c193523b4dbaa1b9bf23542b6d3f.pdf | 89.99 kB | Adobe PDF | View/Open |
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