Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/5428
DC FieldValueLanguage
dc.contributor.authorRolo, Anabela P.-
dc.contributor.authorOliveira, Paulo J.-
dc.contributor.authorMoreno, António J. M.-
dc.contributor.authorPalmeira, Carlos M.-
dc.date.accessioned2008-09-01T15:42:07Z-
dc.date.available2008-09-01T15:42:07Z-
dc.date.issued2001en_US
dc.identifier.citationBiochemical Pharmacology. 61:11 (2001) 1449-1454en_US
dc.identifier.urihttp://hdl.handle.net/10316/5428-
dc.description.abstractIntracellular accumulation of toxic, hydrophobic bile acids has been proposed as one of the putative final common pathways leading to cholestatic liver injury. Furthermore, bile acids have been proposed as a causative factor for hepatic cardiomyopathy. Hepatic tissue concentrations of chenodeoxycholic acid (CDCA) during cholestasis are greater than those of other toxic bile acids. In the presence of calcium and phosphate, CDCA induced the permeability transition pore (PTP) in freshly isolated rat liver mitochondria. In this study, we evaluated the effects of carvedilol, a multirole cardioprotective compound, on CDCA-induced PTP. Mitochondrial membrane potential, osmotic swelling, and calcium fluxes were monitored. CDCA-induced PTP, characterized by membrane depolarization, release of matrix calcium, and osmotic swelling, was prevented by carvedilol. Under the same conditions, its hydroxylated analog BM-910228 did not reveal any protective effect. This finding reinforces carvedilol's therapeutic interest, because it may potentially prevent mitochondrial dysfunction associated with cardiomyopathy in the pathophysiology of cholestatic liver diseaseen_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6T4P-42WG3WD-G/1/dc3c92e4112aa458c42eb91ac53f64d7en_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectChenodeoxycholic aciden_US
dc.subjectCarvedilolen_US
dc.subjectBM-910228en_US
dc.subjectLiver mitochondriaen_US
dc.subjectPermeability transitionen_US
dc.subjectCardiomyopathyen_US
dc.titleProtective effect of carvedilol on chenodeoxycholate induction of the permeability transition poreen_US
dc.typearticleen_US
dc.identifier.doi10.1016/S0006-2952(01)00620-7-
uc.controloAutoridadeSim-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptInstitute of Interdisciplinary Research-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitMARE - Marine and Environmental Sciences Centre-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0003-3535-9630-
crisitem.author.orcid0000-0002-5201-9948-
crisitem.author.orcid0000-0003-3575-7604-
crisitem.author.orcid0000-0002-2639-7697-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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