Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/4841
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cunha, Rodrigo A. | - |
dc.contributor.author | Malva, João O. | - |
dc.contributor.author | Ribeiro, J. A. | - |
dc.date.accessioned | 2008-09-01T14:15:23Z | - |
dc.date.available | 2008-09-01T14:15:23Z | - |
dc.date.issued | 2000 | en_US |
dc.identifier.citation | FEBS Letters. 469:2-3 (2000) 159-162 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/4841 | - |
dc.description.abstract | Kainate receptors are ionotropic receptors, also reported to couple to Gi/Go proteins, increasing neuronal excitability through disinhibition of neuronal circuits. We directly tested in hippocampal synaptosomes if kainate receptor-mediated inhibition of GABA release involved a metabotropic action. The kainate analogue, domoate (3 [mu]M), inhibited by 24% [3H]GABA-evoked release, an effect reduced by 76% in synaptosomes pre-treated with pertussis toxin. Protein kinase C inhibition attenuated by 82% domoate-induced inhibition of GABA release whereas protein kinase C activation did not change kainate receptor binding. Thus, domoate inhibition of GABA release recruits Gi/Go proteins and a protein kinase C pathway. | en_US |
dc.description.uri | http://www.sciencedirect.com/science/article/B6T36-3YRVBPH-6/1/a4d0cd3bf73cd3eea2d7e666afc0bdd4 | en_US |
dc.format.mimetype | aplication/PDF | en |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.subject | Kainate receptor | en_US |
dc.subject | G protein | en_US |
dc.subject | Protein kinase C | en_US |
dc.subject | Hippocampus | en_US |
dc.title | Pertussis toxin prevents presynaptic inhibition by kainate receptors of rat hippocampal [3H]GABA release | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1016/S0014-5793(00)01272-2 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0003-2550-6422 | - |
crisitem.author.orcid | 0000-0002-5438-4447 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
file616abc6b2e7345b3b67d3b49194da4f5.pdf | 115.5 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
58
checked on Apr 15, 2024
Page view(s) 50
554
checked on Apr 16, 2024
Download(s) 20
1,022
checked on Apr 16, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.