Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/4832
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dc.contributor.authorRocha-Pereira, Petronila-
dc.contributor.authorSantos-Silva, Alice-
dc.contributor.authorRebelo, Irene-
dc.contributor.authorFigueiredo, Américo-
dc.contributor.authorQuintanilha, Alexandre-
dc.contributor.authorTeixeira, Frederico-
dc.date.accessioned2008-09-01T14:15:14Z-
dc.date.available2008-09-01T14:15:14Z-
dc.date.issued2001en_US
dc.identifier.citationClinica Chimica Acta. 303:1-2 (2001) 33-39en_US
dc.identifier.urihttps://hdl.handle.net/10316/4832-
dc.description.abstractPsoriasis is a common chronic and recurrent inflammatory skin disorder that has been associated with oxidative stress, abnormal plasma lipid metabolism and with high frequency of cardiovascular events. This prevalence seems to be related to the severity of psoriasis, as it occurs more frequently in patients presenting large areas of the body affected with psoriasis lesions. The aim of our work was to evaluate the development of oxidative stress and of dislipidemia in psoriasis, and to look for a correlation between their levels and worsening of psoriasis. We evaluated lipid profile, total antioxidant capacity, antioxidant vitamins A and E, and lipoperoxidation products. The study was performed in controls and in patients presenting mild and severe psoriasis. Patients presented risk changes in lipid profile (a rise in cholesterol (P<0.01), triglycerides (P<0.001), low density lipoprotein cholesterol (P<0.01), very low density lipoprotein cholesterol (P<0.01), apolipoprotein B (P<0.001) and lipoprotein(a) (P<0.001); and a reduction in high density lipoprotein cholesterol (P<0.001)), a rise in lipoperoxidation products (P<0.001) and a reduction in total antioxidant capacity (P<0.001) and in antioxidant vitamins A (P<0.001) and E (P<0.05). Moreover, we found that the worsening of psoriasis was associated with the enhancement of oxidative stress and of the lipid risk changes. Our data suggest that psoriasis patients must be considered as a group at risk for cardiovascular disease and that this risk seems to be higher in severe psoriasis. In addition, a possible benefit of an enriched diet or of a supplement of vitamins A and E in psoriasis patients should be further studied.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6T57-4239801-4/1/5dce64d938dedc90c152b16534adbff0en_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectPsoriasisen_US
dc.subjectRisk factorsen_US
dc.subjectCardiovascular diseaseen_US
dc.subjectOxidantsen_US
dc.subjectAntioxidantsen_US
dc.subjectSerum lipidsen_US
dc.titleDislipidemia and oxidative stress in mild and in severe psoriasis as a risk for cardiovascular diseaseen_US
dc.typearticleen_US
dc.identifier.doi10.1016/S0009-8981(00)00358-2-
item.openairetypearticle-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextCom Texto completo-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0002-9105-9619-
crisitem.author.orcid0000-0002-2601-0923-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
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