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dc.contributor.authorAmbrósio, António F.en_US
dc.contributor.authorSilva, Ana P.en_US
dc.contributor.authorMalva, João O.en_US
dc.contributor.authorSoares-da-Silva, Patricioen_US
dc.contributor.authorCarvalho, Arsélio P.en_US
dc.contributor.authorCarvalho, Caetana M.en_US
dc.date.accessioned2008-09-01T14:15:11Z-
dc.date.available2008-09-01T14:15:11Z-
dc.date.issued2001en_US
dc.identifier.citationBiochemical Pharmacology. 61:10 (2001) 1271-1275en_US
dc.identifier.urihttp://hdl.handle.net/10316/4829-
dc.description.abstractWe investigated the mechanism(s) of action of two new putative antiepileptic drugs (AEDs), (S)-(-)-10-acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide (BIA 2-093) and 10,11-dihydro-10-hydroxyimino-5H-dibenz[b,f]azepine-5-carboxamide (BIA 2-024), by comparing their effects on the release of endogenous glutamate in hippocampal synaptosomes, with those of carbamazepine (CBZ) and oxcarbazepine (OXC). The AEDs inhibited the release of glutamate evoked by 4-aminopyridine (4-AP) or veratridine in a concentration-dependent manner, being CBZ more potent than the other AEDs. Using conditions of stimulation (30 mM KCl), where Na+ channels are inactivated, the AEDs did not inhibit either the Ca2+-dependent or -independent release of glutamate. The results indicate that BIA 2-093 and BIA 2-024 have sodium channel-blocking properties, but CBZ and OXC are more potent than the new AEDs. Moreover, the present data also indicate that Ca2+ channels coupled to the exocytotic release of glutamate and the activity of the glutamate transporter were not affected by the AEDs.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6T4P-42VM949-B/1/fa9bdc673fba5c5bc75d9e3d94d17f44en_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectAntiepileptic drugsen_US
dc.subjectCarbamazepineen_US
dc.subjectOxcarbazepineen_US
dc.subjectSodium channelsen_US
dc.subjectCalcium channelsen_US
dc.subjectGlutamate releaseen_US
dc.titleInhibition of glutamate release by BIA 2-093 and BIA 2-024, two novel derivatives of carbamazepine, due to blockade of sodium but not calcium channelsen_US
dc.typearticleen_US
item.fulltextCom Texto completo-
item.grantfulltextopen-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
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