Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/4796
DC FieldValueLanguage
dc.contributor.authorMonteiro, Pedro-
dc.contributor.authorDuarte, Ana I.-
dc.contributor.authorMoreno, António-
dc.contributor.authorGonçalves, Lino M.-
dc.contributor.authorProvidência, Luí­s A.-
dc.date.accessioned2008-09-01T14:14:37Z-
dc.date.available2008-09-01T14:14:37Z-
dc.date.issued2003en_US
dc.identifier.citationEuropean Journal of Pharmacology. 482:1-3 (2003) 245-253en_US
dc.identifier.urihttp://hdl.handle.net/10316/4796-
dc.description.abstractCardiac mitochondria may become dysfunctional during ischaemia, thus compromising cardiomyocyte function. Carvedilol is an [alpha]1/[beta]-adrenoceptor antagonist with antioxidant, neuroprotective, cardioprotective and vascularprotective properties, and is used to treat hypertension, myocardial ischaemia and congestive heart failure. However, its impact on mitochondrial function during acute prolonged ischaemia is unknown. We aimed to study the effect of carvedilol on cardiac mitochondrial function during acute ischaemia, using Wistar rat hearts perfused with a Langendorff system, and then submitted to ischaemia in the presence and absence of carvedilol. We determined the electrical potential of the mitochondrial membrane, O2 consumption by the respiratory chain, energy charge and the activity of the mitochondrial respiratory chain complexes. In our model, carvedilol had a preferential action on phosphorylation, increasing the mitochondrial energy charge (0.76±0.03 vs. 0.65±0.01 arbitrary units; P<0.05) and decreasing the phosphorylation lag phase (28.64±4.23 vs. 62.4±11.63 s; P<0.05) during ischaemia. The larger amount of energy available allowed the preservation of the electrical potential (201.2±2.45 vs. 186.66±3.36 mV;P<0.05), thus improving mitochondrial function during acute prolonged ischaemia.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6T1J-49WN14K-6/1/533f7aab84d93b0ce79eb83b830d1ed8en_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectIschaemiaen_US
dc.subjectCarvedilolen_US
dc.subjectMitochondrionen_US
dc.titleCarvedilol improves energy production during acute global myocardial ischaemiaen_US
dc.typearticleen_US
dc.identifier.doi10.1016/j.ejphar.2003.09.042-
uc.controloAutoridadeSim-
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Medicine-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitMARE - Marine and Environmental Sciences Centre-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0003-3575-7604-
crisitem.author.orcid0000-0001-9255-3064-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
Files in This Item:
File Description SizeFormat
file0819ead942a6466bbe72e7ce4e9a99a2.pdf431.24 kBAdobe PDFView/Open
Show simple item record

WEB OF SCIENCETM
Citations

16
checked on Nov 2, 2021

Page view(s) 50

610
checked on Nov 23, 2021

Download(s) 50

574
checked on Nov 23, 2021

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.