Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/47457
DC FieldValueLanguage
dc.contributor.authorFialho, Renata-
dc.contributor.authorPereira, Marco-
dc.contributor.authorBucur, Mihaela-
dc.contributor.authorFisher, Martin-
dc.contributor.authorWhale, Richard-
dc.contributor.authorRusted, Jennifer-
dc.date.accessioned2018-02-05T11:36:43Z-
dc.date.available2018-02-05T11:36:43Z-
dc.date.issued2016-
dc.identifier.citationFialho, R., Pereira, M., Bucur, M., Fisher, M., Whale, R., & Rusted, J. (2016). Cognitive impairment in HIV and HCV co-infected patients: A systematic review and meta-analysis. AIDS Care, 28(12), 1481-1494. doi:10.1080/09540121.2016.1191614por
dc.identifier.urihttps://hdl.handle.net/10316/47457-
dc.description.abstractCognitive impairment has been well documented in human immunodeficiency virus (HIV) and hepatitis C virus (HCV) mono-infections. However, in the context of HIV/HCV co-infection the research is more limited. The aim of this systematic review was to describe the characteristics of cognitive impairment in HIV/HCV co-infection and to examine the differences in cognitive performance between HIV/HCV and HIV and HCV mono-infected patients. Of the 437 records initially screened, 24 papers met the inclusion criteria and were included in the systematic review. Four studies were included in the meta-analysis. Most studies indicated that HIV/HCV co-infected patients had a higher level of cognitive impairment than HIV mono-infected patients. Meta-analysis also indicated that HIV mono-infected patients had a significantly lower global deficit score than co-infected patients. The results also indicated that co-infected patients were more likely to be impaired in information processing speed than HIV mono-infected patients. These findings can be challenged by biasing factors such as the small number of included studies, heterogeneity of the samples and a large diversity of methodological procedures. Future research with consistent and comprehensive neuropsychological batteries and covering a greater diversity of risk factors is needed, in order to clarify the effects of both viruses on cognitive function and the mechanisms that underlie these effects. Because cognitive impairments may pose significant challenges to medication adherence, quality of life and overall functioning, such knowledge may have important implications to the planning and implementation of effective interventions aimed at optimising the clinical management of these infections.por
dc.language.isoengpor
dc.rightsopenAccesspor
dc.subjectCognitive Dysfunctionpor
dc.subjectCoinfectionpor
dc.subjectFemalepor
dc.subjectHIV Infectionspor
dc.subjectHepatitis C, Chronicpor
dc.subjectHumanspor
dc.subjectMalepor
dc.subjectMental Processespor
dc.titleCognitive impairment in HIV and HCV co-infected patients: a systematic review and meta-analysispor
dc.typearticlepor
degois.publication.firstPage1481por
degois.publication.lastPage1494por
degois.publication.issue12por
degois.publication.titleAIDS Carepor
dc.relation.publisherversionhttp://www.tandfonline.com/doi/full/10.1080/09540121.2016.1191614por
dc.peerreviewedyespor
dc.identifier.doi10.1080/09540121.2016.1191614-
degois.publication.volume28por
item.openairetypearticle-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextCom Texto completo-
crisitem.author.researchunitCenter for Research in Neuropsychology and Cognitive Behavioral Intervention-
crisitem.author.orcid0000-0002-6086-2329-
Appears in Collections:FPCEUC - Artigos em Revistas Internacionais
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