Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/4738
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ferreiro, Elisabete | - |
dc.contributor.author | Resende, Rosa | - |
dc.contributor.author | Costa, Rui | - |
dc.contributor.author | Oliveira, Catarina R. | - |
dc.contributor.author | Pereira, Cláudia M. F. | - |
dc.date.accessioned | 2008-09-01T14:13:37Z | - |
dc.date.available | 2008-09-01T14:13:37Z | - |
dc.date.issued | 2006 | en_US |
dc.identifier.citation | Neurobiology of Disease. 23:3 (2006) 669-678 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/4738 | - |
dc.description.abstract | Prion (PrP) and amyloid-[beta] (A[beta]) peptides are involved in the neuronal loss that occurs in Prion disorders (PrD) and Alzheimer's disease (AD), respectively, partially due to Ca2+ dysregulation. Besides, the endoplasmic reticulum (ER) stress has an active role in the neurotoxic mechanisms that lead to these pathologies. Here, we analyzed whether the ER-mediated apoptotic pathway is involved in the toxic effect of synthetic PrP and A[beta] peptides. In PrP106-126- and A[beta]1-40-treated cortical neurons, the release of Ca2+ through ER ryanodine (RyR) and inositol 1,4,5-trisphosphate (IP3R) receptors induces ER stress and leads to increased cytosolic Ca2+ and reactive oxygen species (ROS) levels and subsequently to apoptotic death involving mitochondrial cytochrome c release and caspases activation. These results demonstrate that the early PrP- and A[beta]-induced perturbation of ER Ca2+ homeostasis is a death message that leads to neuronal loss, suggesting that the regulation of ER Ca2+ levels may be a potential therapeutical target for PrD and AD. | en_US |
dc.description.uri | http://www.sciencedirect.com/science/article/B6WNK-4KF1HJF-2/1/1c70b53c2d3ffe42c231154f0fe9258a | en_US |
dc.format.mimetype | aplication/PDF | en |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.subject | Prion disorders | en_US |
dc.subject | Alzheimer's disease | en_US |
dc.subject | Prion peptide | en_US |
dc.subject | Amyloid-β peptide | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Ca2+ homeostasis | en_US |
dc.subject | Endoplasmic reticulum | en_US |
dc.subject | Oxidative stress | en_US |
dc.title | An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1016/j.nbd.2006.05.011 | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-1200-4602 | - |
crisitem.author.orcid | 0000-0002-0504-5756 | - |
crisitem.author.orcid | 0000-0001-6942-4328 | - |
crisitem.author.orcid | 0000-0002-6630-5056 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
fileabfe60f7eb304f3d83050c336c1d4af0.pdf | 529.35 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
187
checked on Mar 25, 2024
WEB OF SCIENCETM
Citations
180
checked on Mar 2, 2024
Page view(s) 50
511
checked on Mar 26, 2024
Download(s) 20
1,034
checked on Mar 26, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.