Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/4721
DC FieldValueLanguage
dc.contributor.authorÁlvaro, Ana Rita-
dc.contributor.authorRosmaninho-Salgado, Joana-
dc.contributor.authorSantiago, Ana Raquel-
dc.contributor.authorMartins, João-
dc.contributor.authorAveleira, Célia-
dc.contributor.authorSantos, Paulo F.-
dc.contributor.authorPereira, Tiago-
dc.contributor.authorGouveia, Denisa-
dc.contributor.authorCarvalho, Ana Luísa-
dc.contributor.authorGrouzmann, Eric-
dc.contributor.authorAmbrósio, António Francisco-
dc.contributor.authorCavadas, Cláudia-
dc.date.accessioned2008-09-01T14:13:20Z-
dc.date.available2008-09-01T14:13:20Z-
dc.date.issued2007en_US
dc.identifier.citationNeurochemistry International. 50:5 (2007) 757-763en_US
dc.identifier.urihttp://hdl.handle.net/10316/4721-
dc.description.abstractNPY is present in the retina of different species but its role is not elucidated yet. In this work, using different rat retina in vitro models (whole retina, retinal cells in culture, microglial cell cultures, rat Müller cell line and retina endothelial cell line), we demonstrated that NPY staining is present in the retina in different cell types: neurons, macroglial, microglial and endothelial cells. Retinal cells in culture express NPY Y1, Y2, Y4 and Y5 receptors. Retina endothelial cells express all NPY receptors except NPY Y5 receptor. Moreover, NPY is released from retinal cells in culture upon depolarization. In this study we showed for the first time that NPY is present in rat retina microglial cells and also in rat Müller cells. These in vitro models may open new perspectives to study the physiology and the potential pathophysiological role of NPY in the retina.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6T0B-4N0X5HW-3/1/e20d17a164f9188cfb71c43dcde59534en_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectNeuropeptide Y (NPY)en_US
dc.subjectRat retinaen_US
dc.subjectMicroglial cellsen_US
dc.subjectMüller cellsen_US
dc.subjectEndothelial cellsen_US
dc.subjectNPY receptorsen_US
dc.subjectNPY releaseen_US
dc.titleNPY in rat retina is present in neurons, in endothelial cells and also in microglial and Müller cellsen_US
dc.typearticleen_US
dc.identifier.doi10.1016/j.neuint.2007.01.010-
uc.controloAutoridadeSim-
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Pharmacy-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0002-6781-8515-
crisitem.author.orcid0000-0002-7541-7041-
crisitem.author.orcid0000-0002-2225-455X-
crisitem.author.orcid0000-0001-8368-6666-
crisitem.author.orcid0000-0002-0477-1641-
crisitem.author.orcid0000-0001-8020-9266-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
Files in This Item:
File Description SizeFormat
file312b257b9bc7472183f4ace99a6ec53a.pdf504.24 kBAdobe PDFView/Open
Show simple item record

WEB OF SCIENCETM
Citations

24
checked on Oct 2, 2021

Page view(s) 50

528
checked on Nov 25, 2021

Download(s) 50

335
checked on Nov 25, 2021

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.